Management of Perioral Dermatitis
Family oil is not recommended for perioral dermatitis treatment as it may worsen the condition due to its greasy nature which can facilitate folliculitis development. 1
Understanding Perioral Dermatitis
Perioral dermatitis is a common acneiform facial eruption characterized by:
- Papulovesicular eruptions in the perioral region with a typical narrow spared zone around the edge of the lips 2
- Can affect both adults and children, with classic form primarily affecting women aged 15-45 years 2
- Variants include lupus-like and granulomatous perioral dermatitis (more common in prepubescent boys) 2, 3
Etiology and Aggravating Factors
The etiopathogenesis remains unclear, but several factors are associated with perioral dermatitis:
- Prolonged use of topical corticosteroids is a common preceding factor 2, 4
- Greasy creams and ointments can worsen the condition by facilitating folliculitis 1
- Skin irritants, physical factors, and hormonal changes contribute to epidermal barrier dysfunction 2
- Manipulation of the skin increases risk of infection and can worsen the condition 1
Treatment Approach
First-Line Treatment
- "Zero therapy" is the treatment of choice for mild forms - discontinuation of all cosmetics and topical corticosteroids 2, 5
- Patients should be warned about the rebound phenomenon that typically occurs after stopping previous topical treatments 2
- Avoid greasy creams or oils (including family oil) as they can worsen the condition 1
Topical Treatments for Moderate Disease
- Topical metronidazole is effective, particularly in children 2, 4
- Topical erythromycin (1% cream) shows good evidence for reducing time to resolution 5
- Topical pimecrolimus can rapidly reduce disease severity, especially after corticosteroid use 2, 5
Systemic Treatment for Severe Cases
- Oral tetracycline in subantimicrobial doses until complete remission is the best validated choice for adults and children over 8 years 2, 4
- For children under 8 years, oral erythromycin is an appropriate alternative 4, 3
- Systemic isotretinoin should be considered only for patients refractory to all standard therapies 2
Skin Care Recommendations
- Use hypoallergenic moisturizing creams that are non-greasy 1
- Avoid manipulation of affected skin areas 1
- Avoid topical steroids as they may cause perioral dermatitis and skin atrophy if used inadequately 1
- Use gentle cleansers instead of soaps and detergents that remove natural lipids from the skin 1
Alternative Treatments
- Photodynamic therapy with topical 5-aminolevulinic acid has shown promising results with 92.1% clearance in one study 6
- Aloe vera may be considered for mild cases in patients who are not allergic to it, though evidence is limited for perioral dermatitis specifically 1
When to Refer to a Specialist
- Diagnostic doubt 1
- Failure to respond to first-line treatments 1
- Severe or worsening symptoms despite appropriate therapy 1
- Need for systemic treatments in children 4
Common Pitfalls to Avoid
- Using topical corticosteroids which can initially improve symptoms but cause rebound flares upon discontinuation 2, 4
- Applying greasy products including oils that can worsen follicular occlusion 1
- Underestimating the importance of patient education and psychological support during treatment 2
- Failing to warn patients about the initial worsening that may occur after stopping topical steroids 2