From the Research
The recommended dosing for desmopressin nasal spray for adults varies by indication, with a typical starting dose of 10 mcg (0.1 mL) in each nostril 1-3 times daily for central diabetes insipidus, and 10 mcg in each nostril at bedtime for primary nocturnal enuresis, as supported by the most recent and highest quality study available 1.
Indications and Dosage
- For central diabetes insipidus, adults typically start with 10 mcg (0.1 mL) in each nostril 1-3 times daily, adjustable based on response, with a usual maintenance dose of 10-40 mcg daily.
- For primary nocturnal enuresis, adults should use 10 mcg in each nostril at bedtime, which can be increased to 20 mcg per nostril if needed.
- For hemophilia A or von Willebrand disease, the dose is 300 mcg (150 mcg in each nostril) to be administered 30 minutes before procedures.
Administration and Precautions
- Patients should be instructed to prime the pump before first use and to avoid blowing their nose for at least 15 minutes after administration for optimal absorption.
- Fluid intake should be restricted from 1 hour before until 8 hours after dosing to prevent hyponatremia, a potential serious side effect.
- Desmopressin works by mimicking antidiuretic hormone (vasopressin), which increases water reabsorption in the kidneys and raises levels of clotting factors in the blood, as described in earlier studies 2, 3.