Differential Diagnosis for White Lesion on Palm
- Single most likely diagnosis
- Callus: This is the most common cause of a white lesion on the palm, resulting from repeated friction or pressure, leading to thickening of the skin.
- Other Likely diagnoses
- Eccrine poroma: A benign tumor of the sweat glands that can appear as a white or flesh-colored lesion on the palm.
- Verruca (wart): Caused by the human papillomavirus, can appear as a white, rough lesion on the palm.
- Lichen planus: An inflammatory condition that can cause white, lacy patches on the skin, including the palms.
- Pityriasis alba: A mild, chronic skin condition characterized by small, round, white patches, often on the face but can occur on palms.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Squamous cell carcinoma: Although rare on the palm, it can present as a white or flesh-colored lesion and is crucial to diagnose early due to its potential for metastasis.
- Melanoma (acral lentiginous): The most common type of melanoma on the palms and soles, which can appear as a new or changing white, black, or brown lesion.
- Rare diagnoses
- Darier's disease: A rare genetic disorder that affects the skin, sometimes presenting with white or pinkish lesions on the palms.
- Tylosis (Howel-Evans syndrome): A rare genetic condition characterized by thickening of the skin on the palms and soles, associated with an increased risk of esophageal cancer.
- Arsenic poisoning: Can cause white lesions or hyperpigmentation on the palms and soles, among other systemic symptoms.