What does an absolute neutrophil count (ANC) of 1217 indicate?

Understanding an Absolute Neutrophil Count of 1217

An absolute neutrophil count (ANC) of 1217 cells/μL indicates mild neutropenia, falling within Grade 2 neutropenia (1000-1500 cells/μL) according to standard hematologic toxicity grading scales. 1

Classification of Neutropenia

• Neutropenia is defined as an ANC below 1500 cells/μL 1, 2
• Severity of neutropenia is classified as follows:
  • Grade 0: ANC ≥2000 cells/μL (normal) 1
  • Grade 1: ANC 1500-2000 cells/μL (mild) 1
  • Grade 2: ANC 1000-1500 cells/μL (moderate) - your result falls here 1
  • Grade 3: ANC 500-1000 cells/μL (severe) 1
  • Grade 4: ANC <500 cells/μL (life-threatening) 1

Clinical Significance

• An ANC of 1217 cells/μL represents a mild to moderate reduction in neutrophil count but is generally not associated with a significantly increased risk of infection 2, 3
• This level is above the critical threshold of 500 cells/μL where the risk of serious infections increases substantially 1
• For patients with Duffy-null status (common in people of African or Middle Eastern descent), this may actually represent a normal neutrophil count, as their reference range is approximately 1210-5390 cells/μL 1

Management Considerations

• For an ANC of 1217 cells/μL without symptoms or risk factors:

  • No specific intervention is typically required 2, 3
  • Monitoring with repeat CBC with differential is recommended 3
  • No antimicrobial prophylaxis is indicated at this level 2

• If the patient is receiving chemotherapy:

  • This level may indicate the need for dose adjustment in certain regimens 1
  • For chronic myelogenous leukemia patients on imatinib, this level would not require holding medication (which is only indicated when ANC <1000 cells/μL) 1
  • First-cycle nadir ANC can predict risk of subsequent neutropenic events during chemotherapy 4

• Special considerations:

  • If fever develops (temperature >38.5°C for >1 hour), this would constitute febrile neutropenia requiring prompt antibiotic therapy 1, 2
  • G-CSF (granulocyte colony-stimulating factor) is not indicated at this ANC level unless there are other risk factors for infection 2

Common Causes of Mild to Moderate Neutropenia

• Medication effect (common with many antibiotics, antipsychotics, and chemotherapy agents) 3, 5
• Viral infections (including COVID-19, influenza, hepatitis) 3
• Benign ethnic neutropenia (particularly in individuals of African, Middle Eastern, or Mediterranean descent) 1, 6
• Autoimmune disorders 3, 5
• Early stage of more serious hematologic disorders 3

Follow-up Recommendations

• For asymptomatic patients with this ANC level:

  • Repeat CBC with differential in 2-4 weeks to assess trend 3
  • Review medication list for potential causes 3, 5
  • If persistent (>3 months), consider hematology consultation 3
  • No special precautions are needed unless the patient is immunocompromised or receiving chemotherapy 2, 3

• For symptomatic patients or those with risk factors:

  • More urgent evaluation may be warranted 2
  • Consider bone marrow examination if accompanied by other cytopenias or if persistent without clear cause 3

Remember that interpretation of ANC should always consider the clinical context, including the patient's baseline values, ethnicity, medication use, and presence of symptoms or other medical conditions.