Is photosensitivity related to ceftriaxone (Ceftriaxone) therapy?

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Last updated: March 25, 2025 • View editorial policy

From the Research

Ceftriaxone does not typically cause sun sensitivity (photosensitivity) as a side effect. Unlike some antibiotics such as tetracyclines (doxycycline, minocycline), fluoroquinolones (ciprofloxacin, levofloxacin), and sulfonamides (sulfamethoxazole), ceftriaxone belongs to the cephalosporin class which is not generally associated with photosensitive reactions 1. Patients taking ceftriaxone do not need to take special precautions regarding sun exposure beyond normal sun protection measures. The most common side effects of ceftriaxone include:

  • Gastrointestinal issues (diarrhea, nausea)
  • Injection site reactions if given intramuscularly
  • Rarely allergic reactions If a patient experiences unusual skin reactions while taking ceftriaxone, they should consult their healthcare provider, as this could indicate an allergic reaction rather than photosensitivity. These reactions would typically manifest as a rash, hives, or itching regardless of sun exposure, rather than as increased sensitivity to sunlight. The provided studies do not mention photosensitivity as a side effect of ceftriaxone, and the most recent study 1 focuses on the pharmacokinetic-pharmacodynamic perspective of ceftriaxone, without mentioning photosensitivity. Therefore, based on the available evidence, ceftriaxone is not associated with an increased risk of photosensitivity.

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