What is the recommended treatment for a headache resulting from head trauma?

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Last updated: October 23, 2025View editorial policy

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Treatment of Headache from Head Trauma

For headaches resulting from head trauma, nonopioid analgesics such as ibuprofen or acetaminophen should be offered as first-line treatment, with careful counseling about the risks of analgesic overuse and rebound headache. 1

Acute Management Algorithm

Initial Assessment and Imaging

  • For severe or worsening headache after mild traumatic brain injury (mTBI), healthcare professionals should consider obtaining a head CT to evaluate for intracranial complications, especially when associated with other risk factors 1
  • Children with acutely worsening headache symptoms during observation periods should undergo emergent neuroimaging 1
  • For headaches related to remote trauma, MRI without contrast is the preferred imaging modality, particularly when neurologic signs/symptoms are present or headaches are increasing in frequency, duration, or severity 1

Pharmacological Management

  • Provide nonopioid analgesia (ibuprofen or acetaminophen) for painful headaches after acute mTBI 1
  • Avoid opioids for headache management as they are not generally recommended for headache therapy 1
  • Do not administer 3% hypertonic saline for treatment of acute headache after mTBI outside of research settings 1
  • For severe headaches unresponsive to acetaminophen, consider adjunctive therapy with metoclopramide 10 mg orally, administered 20-30 minutes before or with acetaminophen 2

Chronic Management

For Persistent Post-Traumatic Headaches

  • Refer patients with chronic headache after mTBI for multidisciplinary evaluation and treatment 1
  • Consider analgesic overuse as a potential contributory factor in chronic post-traumatic headaches 1
  • Post-traumatic headaches often resemble migraine or tension-type headaches and should be treated according to their predominant characteristics 3, 4, 5

Additional Interventions

  • For patients with persistent vestibulo-oculomotor dysfunction after mTBI, consider referral to a program of vestibular rehabilitation 1
  • Provide guidance on proper sleep hygiene methods to facilitate recovery 1
  • If sleep problems persist despite appropriate sleep hygiene measures, consider referral to a sleep disorder specialist 1

Important Considerations and Pitfalls

  • Limit use of acute headache medications to avoid medication overuse headache, which can occur with frequent use (typically more than 2-3 days per week) 6
  • Be vigilant for signs of worsening that may indicate more severe injury, including:
    • Severe or worsening headache 1
    • Headaches associated with vomiting 1
    • Neurological deficits 1
  • Post-traumatic headache can be persistent, with up to 25% of patients experiencing chronic headaches as long-term residua 3
  • The milder the traumatic brain injury, the more likely the development of headaches, which is a paradoxical relationship that clinicians should be aware of 3, 5

Non-Pharmacological Approaches

  • Encourage adequate hydration and rest in a quiet, dark environment 2
  • Apply cool compresses to the forehead for symptomatic relief 2
  • Consider physical therapy interventions, especially for headaches with cervical components 3
  • Cognitive behavioral approaches may be beneficial for managing chronic post-traumatic headaches 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Medication Management for Headache in Dengue Patients

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Post-traumatic headaches.

Handbook of clinical neurology, 2015

Research

Post-traumatic headaches: a clinical overview.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014

Guideline

Migraine Management in Adult Males

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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