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Last updated: October 23, 2025View editorial policy

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Differential Diagnosis for Pain on Sides of Abdomen

Single Most Likely Diagnosis

  • Musculoskeletal strain: This is often the most common cause of abdominal side pain, resulting from overuse or injury to the muscles in the abdominal wall. The pain is typically sharp and localized to one area.

Other Likely Diagnoses

  • Kidney stones: Pain from kidney stones can radiate to the sides of the abdomen, especially if the stones are moving down the ureters. The pain is often severe and may be accompanied by nausea, vomiting, and blood in the urine.
  • Urinary tract infection (UTI): While UTIs more commonly cause pain in the lower abdomen or pelvic area, they can also cause flank pain that radiates to the sides of the abdomen, especially if the infection has moved up to the kidneys.
  • Constipation: Severe constipation can cause abdominal pain that may be felt on the sides, due to the buildup of stool in the intestines and the subsequent pressure on the abdominal wall.

Do Not Miss Diagnoses

  • Appendicitis: Although appendicitis typically causes pain in the lower right abdomen, it can sometimes cause pain on the sides if the appendix is located in a retrocecal position. Missing this diagnosis can lead to perforation and severe complications.
  • Ectopic pregnancy: In women, an ectopic pregnancy can cause severe abdominal pain, including pain on the sides, and is a medical emergency that requires immediate attention.
  • Pulmonary embolism: In rare cases, a pulmonary embolism can cause referred pain to the abdomen, including the sides, especially if the embolism is large and causes significant strain on the lungs and diaphragm.

Rare Diagnoses

  • Inflammatory bowel disease (IBD): Conditions like Crohn's disease and ulcerative colitis can cause chronic abdominal pain, including pain on the sides, although this is less common.
  • Abdominal aortic aneurysm: A large aneurysm can cause pain in the abdomen, including the sides, due to pressure on surrounding structures, although this is more typically felt in the mid-back or lower abdomen.
  • Pancreatitis: Pancreatic inflammation can cause severe abdominal pain that may radiate to the sides, although this is more commonly felt in the upper abdomen.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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