What are the diagnostic steps and treatment options for an ankle sprain?

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Ankle Sprain Diagnosis and Treatment

For diagnosing ankle sprains, the Ottawa Ankle Rules should be used as the primary tool to rule out fractures, followed by delayed physical examination 4-5 days post-injury for optimal assessment of ligament damage. 1, 2

Diagnostic Steps

Initial Assessment

  • Apply the Ottawa Ankle Rules to rule out fractures with high sensitivity (86-99%) and determine if radiography is needed 1
  • Ottawa Ankle Rules criteria include:
    • Pain on the dorsal side of one or both malleoli
    • Palpation pain at the base of the fifth metatarsal bone
    • Palpation pain of the navicular bone
    • Inability to walk at least four steps 1

Physical Examination

  • Delay comprehensive ligament assessment by 4-5 days post-injury for optimal sensitivity (84%) and specificity (96%) 1
  • Look for presence of haematoma, pain on palpation around distal fibula, and positive anterior drawer test to identify lateral ligament rupture 1
  • Classify ankle sprains into three grades 1:
    • Grade I: Mild sprain
    • Grade II: Moderate sprain with microligament lesions
    • Grade III: Severe sprain with full ligament lesion

Advanced Imaging

  • MRI should be considered only for suspected high-grade ligament injuries, osteochondral defects, syndesmotic injuries, or occult fractures (sensitivity 93-96%, specificity 100%) 1
  • Ultrasonography has good sensitivity (92%) but lacks specificity (64%) compared to delayed physical examination 1
  • Stress radiographs and arthrography are not recommended due to limited diagnostic value and invasiveness 1

Treatment Protocol

Immediate Care (0-72 hours)

  • RICE (Rest, Ice, Compression, Elevation) may be used initially, though evidence for efficacy is limited 1
  • Cryotherapy combined with exercise therapy is more effective for reducing swelling than heat application 1
  • NSAIDs may reduce pain and swelling but could potentially suppress the natural healing process 1

Functional Treatment (Days 3-14)

  • Use tape or a brace for functional support rather than immobilization 1, 2
  • Semi-rigid ankle braces are preferred over elastic bandages for Grade II sprains 2
  • Begin supervised exercise-based rehabilitation focusing on:
    • Range of motion exercises
    • Isometric strengthening
    • Non-weight bearing balance exercises 2

Rehabilitation (Week 2 onward)

  • Progress to supervised exercise program focusing on proprioception, strength, and coordination 2
  • Functional rehabilitation is superior to immobilization for recovery 3
  • Surgery should be reserved only for cases that do not respond to comprehensive exercise-based treatment 1, 2

Prevention of Recurrence

  • Ankle braces should be used for preventing recurrent lateral ankle sprains 2
  • Supervised balance and coordination training significantly reduces risk of recurrent sprains 2
  • Address negative prognostic factors early, including:
    • Current level of pain
    • Workload demands
    • Level of sports participation 1

Common Pitfalls to Avoid

  • Complete immobilization delays recovery and shows no benefits 2
  • Relying solely on passive modalities without implementing active exercise program 2
  • Using MRI in acute settings when delayed physical examination is sufficient 1
  • Failing to address risk factors for chronic ankle instability, which develops in approximately 20% of acute ankle sprains 4

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Management of Ankle Sprains

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Prevention and treatment of ankle sprain in athletes.

Sports medicine (Auckland, N.Z.), 2003

Research

Acute and chronic lateral ankle instability in the athlete.

Bulletin of the NYU hospital for joint diseases, 2011

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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