Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 23, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Fullness and Swelling with Palpable Cyst-like Mass

Single Most Likely Diagnosis

  • Lipoma: A benign tumor composed of fat tissue, which can present as a palpable, cyst-like mass and is consistent with the normal neck ultrasound and thyroid findings.

Other Likely Diagnoses

  • Cystic Hygroma: A congenital anomaly that can present as a cyst-like mass in the neck, although it's more common in children, it can also be diagnosed in adults.
  • Branchial Cleft Cyst: A congenital anomaly that can present as a cyst-like mass in the neck, typically anterior to the sternocleidomastoid muscle.
  • Thyroglossal Duct Cyst: A congenital anomaly that can present as a midline or slightly off-midline cyst-like mass, although the normal thyroid ultrasound makes this less likely.

Do Not Miss Diagnoses

  • Metastatic Lymph Node: Although the neck ultrasound is normal, it's essential to consider the possibility of a metastatic lymph node, especially if there's a history of cancer.
  • Parathyroid Adenoma: A benign tumor of the parathyroid gland that can present as a palpable mass, although it's typically smaller and more commonly associated with hyperparathyroidism.
  • Thyroid Nodule: Although the thyroid ultrasound is normal, it's crucial to consider the possibility of a thyroid nodule, especially if there are any symptoms of thyroid dysfunction.

Rare Diagnoses

  • Dermoid Cyst: A rare congenital anomaly that can present as a cyst-like mass in the neck.
  • Teratoma: A rare tumor that can contain several different types of tissues and present as a cyst-like mass in the neck.
  • Carotid Body Tumor: A rare tumor of the carotid body that can present as a palpable mass in the neck, although it's typically more lateral and associated with the carotid artery.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.