Does Methotrexate (MTX) kill parasites?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 25, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

Methotrexate is not used to kill parasites, and its use in treating parasitic infections is not supported by medical evidence. Methotrexate is an antimetabolite medication primarily used to treat certain cancers, autoimmune disorders like rheumatoid arthritis, psoriasis, and inflammatory bowel disease. It works by inhibiting the metabolism of folic acid, which interferes with cell division and growth. For parasitic infections, different medications are typically prescribed depending on the specific parasite involved. Common antiparasitic medications include metronidazole for giardiasis and amebiasis, praziquantel for schistosomiasis and tapeworms, albendazole or mebendazole for intestinal worms, and combinations of medications for malaria. These antiparasitic drugs work through various mechanisms such as disrupting the parasite's cell membrane, interfering with their metabolic processes, or paralyzing the organisms. If you suspect a parasitic infection, it's essential to consult a healthcare provider for proper diagnosis and appropriate antiparasitic treatment rather than using methotrexate, which would be ineffective against parasites and could cause serious side effects, as noted in studies such as 1.

Some key points to consider when treating parasitic infections include:

  • The specific type of parasite involved
  • The severity of the infection
  • The patient's overall health and medical history
  • The potential side effects and interactions of antiparasitic medications, as discussed in studies like 2 and 3
  • The importance of proper diagnosis and treatment to prevent complications and improve outcomes, as highlighted in 4 and 5

In general, methotrexate is not a suitable treatment option for parasitic infections, and its use in this context is not supported by medical evidence. Instead, healthcare providers should rely on established antiparasitic medications and treatment protocols to ensure effective and safe treatment of parasitic infections.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.