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Differential Diagnosis for Painful Neck Glands

Single Most Likely Diagnosis

  • Viral Pharyngitis: This is often the most common cause of painful neck glands, typically resulting from a viral infection such as mononucleosis or the common cold. The painful lymph nodes are usually a response to the infection in the throat.

Other Likely Diagnoses

  • Strep Throat: A bacterial infection caused by Group A Streptococcus, which can lead to swollen and painful lymph nodes in the neck.
  • Tonsillitis: Inflammation of the tonsils, which can be caused by either viral or bacterial infections, leading to pain and swelling in the neck glands.
  • Mononucleosis (Mono): Caused by the Epstein-Barr virus, it leads to fever, sore throat, and swollen lymph nodes, particularly in the neck.
  • Lymphadenitis: An infection of the lymph nodes themselves, which can be caused by bacteria or other pathogens, leading to pain and swelling.

Do Not Miss Diagnoses

  • Hodgkin Lymphoma: A type of cancer that affects the immune system and can cause swollen lymph nodes, including those in the neck. Although less common, it's critical to diagnose early.
  • Tuberculosis (TB): A bacterial infection that can affect the lungs but also cause swollen and painful lymph nodes in the neck.
  • Lymphoma (Non-Hodgkin): Another type of cancer affecting the immune system, which can present with swollen lymph nodes.
  • Human Immunodeficiency Virus (HIV): Infection with HIV can lead to persistent generalized lymphadenopathy, including painful neck glands.

Rare Diagnoses

  • Cat-Scratch Disease: Caused by the bacterium Bartonella henselae, transmitted through cat scratches or bites, leading to swollen and painful lymph nodes.
  • Toxoplasmosis: A parasitic infection that can cause swollen lymph nodes, particularly in individuals with weakened immune systems.
  • Sarcoidosis: A condition that leads to the formation of granulomas in various parts of the body, including the lymph nodes, which can cause swelling and pain.
  • Kikuchi-Fujimoto Disease: A rare condition of the lymph nodes, characterized by painful swelling, typically in the neck, and is often self-limiting.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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