Chronic Pancreatitis: This condition can present with minimal or no pain and normal lipase levels, especially in the later stages. Chronic inflammation can lead to fibrosis and atrophy of the pancreas, reducing its ability to produce enzymes, including lipase.

Pancreatic Cancer: Some pancreatic cancers, especially those located in the tail of the pancreas, may not cause significant pain or elevate lipase levels until late in the disease process.
Autoimmune Pancreatitis: This form of pancreatitis is characterized by an autoimmune inflammatory process and can present with minimal symptoms, including pain, and may not always have elevated lipase levels.
Gallstone Pancreatitis with Spontaneous Stone Passage: If a gallstone passes through the ampulla of Vater and into the intestine, the obstruction is relieved, and symptoms, including pain, may resolve, and lipase levels may return to normal.

Peptic Ulcer Disease with Pancreatic Involvement: Although peptic ulcers typically present with pain, in some cases, especially if the ulcer erodes into the pancreas, there might be minimal pain and no significant elevation of lipase.
Ischemic Pancreatitis: This rare condition, caused by reduced blood flow to the pancreas, can present atypically, with minimal pain and normal lipase levels, but it requires prompt diagnosis to prevent further pancreatic damage.

Genetic Disorders (e.g., Hereditary Pancreatitis): These conditions can lead to recurrent episodes of pancreatitis, which might not always follow the typical pattern of pain and elevated lipase.
Drug-Induced Pancreatitis: Certain medications can cause pancreatitis without the typical symptoms of pain or elevated lipase levels.
Infectious Pancreatitis (e.g., due to viral infections like mumps or coxsackievirus): These infections can cause pancreatitis with atypical presentations, including minimal pain and normal lipase levels.