From the Research
To treat dexamethasone-induced hiccups, first try non-pharmacological approaches such as drinking water from the opposite side of a glass, holding your breath, or breathing into a paper bag for a few minutes, as these methods are simple and may help alleviate symptoms 1. If these methods don't work, medication options include metoclopramide, which has been shown to be effective in treating hiccups induced by dexamethasone 2. Some key points to consider when treating dexamethasone-induced hiccups include:
- Reducing the dexamethasone dose if possible, as hiccups are a dose-dependent side effect related to steroid-induced changes in the central nervous system and diaphragmatic irritability 3
- Avoiding carbonated beverages, which can worsen hiccups
- Staying hydrated to help alleviate symptoms
- Considering the addition of a proton pump inhibitor like omeprazole 20mg daily, as gastric irritation can contribute to hiccups
- If hiccups persist beyond 48 hours despite these interventions, contacting a healthcare provider for further evaluation is necessary, as dexamethasone can cause persistent hiccups that significantly diminish patient quality of life 4 It's also important to note that dexamethasone should be used cautiously, and clinicians must be aware of this undesirable effect, as highlighted in a recent case report 4. In terms of medication options, metoclopramide 10mg orally or IV every 6 hours is a recommended treatment for dexamethasone-induced hiccups, as it has been shown to be effective in preventing hiccups in patients who cannot discontinue dexamethasone therapy 2. Other medication options, such as baclofen or chlorpromazine, may also be considered, but metoclopramide is a preferred choice due to its efficacy and safety profile 1.