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Differential Diagnosis for Intermittent, Sharp RUQ Pain in an 18-Year-Old Female

Single Most Likely Diagnosis

  • Biliary colic: This condition is characterized by intermittent, sharp pain in the right upper quadrant (RUQ) due to gallstones obstructing the cystic duct or common bile duct. It's a common cause of RUQ pain in young females, especially if they have risk factors such as obesity or a family history of gallstones.

Other Likely Diagnoses

  • Peptic ulcer disease: Although more common in older adults, peptic ulcers can occur in young females, especially those using NSAIDs or infected with H. pylori. The pain is typically sharp and localized to the RUQ or epigastric area.
  • Functional dyspepsia: This condition involves recurring signs and symptoms of indigestion that have no obvious cause. Symptoms can include sharp pain or discomfort in the upper abdomen.
  • Hepatitis: Viral hepatitis can cause RUQ pain, although it's often accompanied by other symptoms like jaundice, fatigue, and loss of appetite.

Do Not Miss Diagnoses

  • Cholecystitis: Inflammation of the gallbladder, usually due to a gallstone obstructing the cystic duct. It can lead to severe complications like gangrene or perforation if not promptly treated.
  • Pyogenic liver abscess: A rare but potentially life-threatening condition that requires immediate medical attention. Symptoms can include RUQ pain, fever, and jaundice.
  • Pneumonia (right lower lobe): Referred pain from the right lower lobe of the lung can sometimes be perceived as RUQ pain. It's essential to consider pulmonary causes, especially if the patient has respiratory symptoms.

Rare Diagnoses

  • Fitz-Hugh-Curtis syndrome: A rare condition characterized by inflammation of the liver capsule and adjacent peritoneal surfaces, often due to pelvic inflammatory disease. It can cause sharp RUQ pain.
  • Hepatic artery aneurysm: A rare but potentially life-threatening condition that can cause RUQ pain, although it's often accompanied by other symptoms like a palpable mass or signs of hemodynamic instability.
  • Porphyria: A group of rare genetic disorders that can cause acute intermittent porphyria, characterized by severe abdominal pain, including RUQ pain, among other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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