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Differential Diagnoses for 17yo Female with Fatigue and Joint Pain

Single Most Likely Diagnosis

  • Juvenile Idiopathic Arthritis (JIA): This is the most likely diagnosis given the patient's age and the symmetric, polyarticular joint pain. JIA is a chronic autoimmune disease that can cause joint inflammation and damage.

Other Likely Diagnoses

  • Systemic Lupus Erythematosus (SLE): An autoimmune disease that can cause joint pain, fatigue, and other systemic symptoms. It is more common in females and can present in adolescence.
  • Rheumatoid Arthritis (RA): Although less common in adolescents, RA can cause symmetric polyarthritis, fatigue, and other systemic symptoms.
  • Fibromyalgia: A condition characterized by widespread musculoskeletal pain, fatigue, and tender points. It can be difficult to diagnose, but the presence of fatigue and joint pain makes it a consideration.

Do Not Miss Diagnoses

  • Lyme Disease: A bacterial infection that can cause joint pain, fatigue, and other systemic symptoms. It is essential to consider this diagnosis, especially if the patient has a history of tick exposure.
  • Cancer (e.g., Leukemia, Lymphoma): Although rare, cancer can cause joint pain, fatigue, and other systemic symptoms. It is crucial to rule out these diagnoses to avoid delayed treatment.
  • Osteomyelitis or Septic Arthritis: Infections of the bone or joint can cause severe pain, fatigue, and systemic symptoms. Prompt diagnosis and treatment are essential to prevent long-term damage.

Rare Diagnoses

  • Sarcoidosis: A condition that can cause joint pain, fatigue, and other systemic symptoms due to granulomatous inflammation. It is rare in adolescents, but can be considered if other diagnoses are ruled out.
  • Mixed Connective Tissue Disease: An autoimmune disease that can cause joint pain, fatigue, and other systemic symptoms. It is rare and can be difficult to diagnose, but should be considered if other diagnoses are ruled out.
  • Relapsing Polychondritis: A rare condition that can cause joint pain, fatigue, and other systemic symptoms due to inflammation of cartilaginous structures. It is essential to consider this diagnosis if other diagnoses are ruled out.

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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