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Last updated: October 23, 2025View editorial policy

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Differential Diagnosis for Left Axillary Node Pain

Single Most Likely Diagnosis

  • Breast Cancer: The most common cause of axillary lymph node pain, especially in women, is breast cancer. The axillary lymph nodes are a common site for metastasis from breast tumors.

Other Likely Diagnoses

  • Infectious Causes (e.g., Cellulitis, Abscess): Infections in the arm or chest can spread to the axillary lymph nodes, causing pain and swelling.
  • Lymphadenitis: Inflammation of the lymph nodes due to infection or other causes can lead to pain in the axillary region.
  • Cat Scratch Disease: Caused by Bartonella henselae, this infection is transmitted through cat scratches or bites and can lead to axillary lymphadenopathy.

Do Not Miss Diagnoses

  • Lymphoma: Both Hodgkin's and non-Hodgkin's lymphoma can present with lymph node enlargement and pain, including in the axillary region. Missing this diagnosis could lead to delayed treatment of a potentially life-threatening condition.
  • Metastatic Cancer: Cancers other than breast cancer, such as lung, melanoma, or gastrointestinal cancers, can metastasize to the axillary lymph nodes, causing pain.

Rare Diagnoses

  • Sarcoidosis: A systemic disease that can cause lymphadenopathy, including in the axillary region, though it is less common.
  • Kikuchi Disease: A rare form of lymphadenitis that can cause axillary lymph node pain, more commonly seen in young women.
  • Silicone Implant-Associated Lymphadenopathy: In individuals with silicone breast implants, there can be a reaction that leads to lymphadenopathy, including in the axillary nodes.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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