What is the comparison between Rexulti (brexpiprazole) and Abilify (aripiprazole) for sedation?

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Rexulti vs Abilify for Sedation

Abilify (aripiprazole) is less sedating than most antipsychotics and has a lower sedation profile compared to other options, while Rexulti (brexpiprazole) has even less propensity for sedation due to its pharmacological profile. 1, 2

Pharmacological Differences

  • Brexpiprazole (Rexulti) displays less intrinsic activity at D2 receptors compared to aripiprazole (Abilify), which contributes to its lower propensity for activating adverse events 2
  • Both medications are partial agonists at dopamine D2 and serotonin 5-HT1A receptors and antagonists at serotonin 5-HT2A receptors, but with different receptor binding profiles 3, 4
  • Brexpiprazole's receptor binding profile shows actions at 5HT1A, 5HT2A and noradrenaline α1B receptors that are at least as potent as its action at D2 receptors, resulting in fewer activating side effects 2

Sedation Profiles

  • Aripiprazole has a lower sedation profile compared to many other antipsychotics (such as olanzapine and quetiapine), making it a preferable option when sedation is a concern 1
  • Brexpiprazole is characterized by a relatively low incidence of both activating and sedating adverse effects compared to other antipsychotics 2
  • Clinical evidence suggests brexpiprazole has an even lower propensity for sedation than aripiprazole due to its modified receptor binding profile 2, 3

Clinical Considerations

  • Aripiprazole's lack of a sedative effect does not impact its efficacy in controlling symptoms such as mania and agitation 5
  • Brexpiprazole was generally well tolerated in clinical trials with a favorable adverse event profile, including low rates of sedation 2
  • When treating patients where minimal sedation is desired, aripiprazole may be preferred over more sedating antipsychotics, but brexpiprazole may offer even less sedation 1, 2

Side Effect Comparison

  • Aripiprazole is associated with more akathisia (an activating side effect) compared to some other antipsychotics 6
  • Common side effects of aripiprazole include headache, agitation, anxiety, insomnia, dizziness, and drowsiness 1
  • Brexpiprazole shows small changes in metabolic parameters that are not clinically significant and moderate weight gain 2

Practical Recommendations

  • For patients where sedation is a significant concern, brexpiprazole would be the preferred choice over aripiprazole based on its pharmacological profile 2, 3
  • In situations where cost is a factor, aripiprazole may be more accessible and still offers a relatively low sedation profile compared to many other antipsychotics 1, 5
  • Lower doses of either medication should be considered for elderly patients, those with hepatic impairment, or poor metabolizers of cytochrome P450 2D6 1

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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