From the Research
Dextromethorphan can potentially lower blood pressure, particularly when used in combination with other medications like amlodipine, as evidenced by a study published in 2016 1. The effect of dextromethorphan on blood pressure is a topic of interest, especially in individuals with existing hypertension or those taking certain medications.
- The study published in 2016 1 found that the combination of low-dose dextromethorphan with amlodipine improved blood pressure reduction in hypertensive patients.
- Another study published in 2012 2 found that low-dose dextromethorphan reduced blood pressure and enhanced vascular protection in experimental hypertension.
- However, it is essential to note that the effects of dextromethorphan on blood pressure can vary from person to person, and higher doses may have different effects, as seen in a study published in 2012 3 where high doses of dextromethorphan produced effects similar to classic hallucinogens, including increases in blood pressure.
- Normal therapeutic doses of dextromethorphan (typically 15-30mg every 4-6 hours, not exceeding 120mg daily) are generally considered safe for most people with controlled blood pressure.
- If you have high blood pressure or cardiovascular issues, it is crucial to consult your healthcare provider before using dextromethorphan-containing products, especially if you are taking medications like MAO inhibitors, selective serotonin reuptake inhibitors (SSRIs), or certain blood pressure medications.
- The mechanism behind dextromethorphan's blood pressure effects involves its action on certain neurotransmitters and receptors in the brain that can influence cardiovascular regulation, as discussed in a review published in 2022 4.