How to Calculate Tamiflu Dosage for 22mg from a 30mg Tablet
To achieve a 22mg dose of Tamiflu (oseltamivir) from a 30mg tablet, you should mix the entire tablet with 10ml of water and then administer 7.3ml of this suspension.
Calculation Method
- For the 6 mg/mL commercial suspension, a 30mg dose is given with 5mL of oral suspension 1
- When mixing a 30mg tablet with 10mL of water, the concentration becomes 3mg/mL (30mg ÷ 10mL) 2
- To calculate the volume needed for 22mg:
- 22mg ÷ 3mg/mL = 7.3mL 2
Administration Guidelines
- Oseltamivir is available as Tamiflu in 30mg, 45mg, and 75mg capsules and as a powder for oral suspension 1, 3
- When the commercially manufactured oral suspension is not available, tablets can be mixed with a sweetened liquid 1
- For accurate dosing, use an appropriate oral dosing device that can measure the calculated volume precisely 2
Important Considerations
- Administration with meals may improve gastrointestinal tolerability 3, 2
- Ensure the tablet is completely dissolved in water before administering the calculated dose 2
- After mixing, the suspension should be used immediately for best results 2
- Oseltamivir is most effective when started within 48 hours of symptom onset 4
Dosing in Special Populations
- For patients with renal impairment (creatinine clearance 10-30 mL/min), dose adjustments are recommended 3
- For preterm infants, lower weight-based dosing is recommended due to immature renal function 1, 3
- Weight-based dosing is preferred for children, with specific recommendations based on body weight 1