What are the five most common side effects associated with Sildenafil (Viagra)?

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From the Guidelines

The five most common side effects associated with Sildenafil (Viagra) are dyspepsia, headache, flushing, back pain, and nasal congestion, as reported in the most recent and highest quality study 1. These side effects are typically mild and temporary, usually resolving within a few hours as the medication leaves the system. The most frequently reported adverse events in men using PDE5i, such as sildenafil, are:

  • Dyspepsia
  • Headache
  • Flushing
  • Back pain
  • Nasal congestion Average rates are similar across medications, with the exception of dyspepsia, flushing, and myalgia, which have varying rates depending on the specific PDE5i used 1. It is essential to note that while these side effects are common, more serious but rare side effects can include priapism, sudden hearing or vision loss, and cardiovascular events, which require immediate medical attention. In clinical practice, it is crucial to inform patients about the potential side effects of sildenafil and monitor them closely for any adverse reactions, especially if they have underlying medical conditions or are taking other medications that may interact with PDE5i 1.

From the FDA Drug Label

The most common side effects with sildenafil tablets include: Nosebleed, headache, upset stomach, getting red or hot in the face (flushing), trouble sleeping, as well as fever, erection increased, respiratory infection, nausea, vomiting, bronchitis, pharyngitis, runny nose, and pneumonia in children.

The five most common side effects associated with Sildenafil (Viagra) are:

  • Nosebleed
  • Headache
  • Upset stomach
  • Flushing (getting red or hot in the face)
  • Trouble sleeping 2

From the Research

Common Side Effects of Sildenafil (Viagra)

The most common side effects associated with Sildenafil (Viagra) are:

  • Headache 3, 4, 5, 6
  • Flushing 3, 4, 5, 6
  • Dyspepsia 3, 4, 5
  • Nasal congestion 4, 5
  • Abnormal vision or transient visual changes 5, 6

Additional Information

These side effects are generally dose-dependent and well-tolerated 4. The use of Sildenafil is extremely safe when taken under proper conditions and in the recommended single-dose range of 25-100 mg 3. However, it is essential to consider contraindications, such as the use of organic nitrates, and caution in patients with certain cardiovascular conditions 3, 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

The clinical safety of viagra.

Annals of the New York Academy of Sciences, 2002

Research

Sildenafil.

Expert opinion on pharmacotherapy, 1999

Research

Sildenafil (viagra) and the heart.

Journal of family & community medicine, 2001

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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