From the FDA Drug Label
In uncomplicated urinary tract infections, skin and skin-structure infections, disseminated gonococcal infections, and uncomplicated pneumonia, a 750 mg dose every 8 hours is recommended. The appropriate dosing of Cefuroxime for a simple Urinary Tract Infection (UTI) is 750 mg every 8 hours 1.
- The duration of treatment is typically 5 to 10 days.
- It is essential to note that doses smaller than those indicated should not be used.
- In patients with impaired renal function, the dosage should be adjusted according to the degree of renal impairment.
From the Research
Dosing of Cefuroxime for Simple UTI
- The appropriate dosing of Cefuroxime for a simple Urinary Tract Infection (UTI) is 250 mg twice daily 2, 3.
- This dosing regimen has been shown to be effective in treating uncomplicated UTIs, with a success rate of 97% 3.
- A single daily dose of 250 mg of cefuroxime axetil, a prodrug of cefuroxime, has also been studied and found to be effective in treating acute uncomplicated UTIs, with a cure rate of 86% 4.
- However, it is worth noting that the use of cefuroxime for UTIs is generally considered alternative to other antibiotics, such as trimethoprim sulfamethoxazole, and should be guided by susceptibility testing 2.
- The efficacy of cefuroxime against common UTI pathogens, such as Escherichia coli, has been demonstrated in several studies 2, 3, 4.
Comparison with Other Antibiotics
- Cefuroxime has been compared to other antibiotics, such as cefaclor and amoxycillin/clavulanate, and found to be equally effective in treating uncomplicated UTIs 3.
- However, cefotaxime, a third-generation cephalosporin, has been shown to be superior to cefuroxime in treating complicated and hospital-acquired UTIs 5.
- Cefixime, another oral cephalosporin, has also been studied for the treatment of UTIs and found to be effective, particularly in uncomplicated cases 6.