Are heavy feeling, brain fog, and wobbly legs normal side effects 2 days after a Venofer (iron sucrose) infusion and is it safe to resume Adderall (amphetamine and dextroamphetamine)?

Management of Venofer Side Effects and Adderall Resumption

The symptoms you're experiencing (heavy feeling, brain fog/lightheadedness, and wobbly legs) 2 days after Venofer infusion are consistent with known delayed infusion reactions, and it is advisable to wait until these symptoms resolve before resuming Adderall to avoid potential cardiovascular complications.

Understanding Delayed Reactions to Venofer (Iron Sucrose)

• Delayed infusion reactions from iron sucrose can occur several hours to days after the infusion, commonly presenting as flu-like symptoms, arthralgias, myalgias, and fever which typically last up to 24 hours 1
• These reactions are generally self-limiting and can be managed with non-steroidal anti-inflammatory drugs (NSAIDs) 1
• Symptoms lasting more than a few days should be evaluated by a healthcare provider as they may indicate other issues such as hypophosphatemia 1

Your Specific Symptoms

• The heavy feeling, brain fog/lightheadedness, and wobbly legs you're experiencing are consistent with known side effects of iron sucrose infusion 2, 3
• The FDA drug label for Venofer lists similar adverse reactions including dizziness, joint aches, paresthesia, and muscle pain 3
• These symptoms can occur following the first dose or subsequent doses of Venofer and may appear up to 30 minutes after administration but can persist 3

Considerations for Resuming Adderall

• Adderall (amphetamine-dextroamphetamine) acts primarily on dopamine and norepinephrine transporters, causing increased extracellular concentrations of these neurotransmitters 4
• This medication can cause cardiovascular effects including tachycardia and hypertension, which could potentially exacerbate any lingering cardiovascular effects from the iron infusion 4, 5
• Prolonged use of Adderall has been associated with adverse cardiovascular effects, making it important to ensure your body has fully recovered from the iron infusion before resuming this medication 5

Recommendations

• Wait until your symptoms from the Venofer infusion completely resolve before resuming Adderall 1, 4
• If symptoms persist beyond 24-48 hours, contact your healthcare provider for evaluation 1
• Consider adequate hydration to help clear the iron and reduce symptoms 6
• When resuming Adderall, start with your prescribed dose as directed by your healthcare provider 4

Important Cautions

• Combining Adderall with unresolved side effects from Venofer could potentially increase cardiovascular stress 4, 5
• If you experience worsening symptoms such as severe dizziness, chest pain, severe headache, or difficulty breathing after resuming Adderall, seek immediate medical attention 4, 7
• Remember that symptoms lasting more than a few days after iron infusion may require medical evaluation 1