From the Guidelines
Niacinamide and nicotinamide are essentially the same compound, with both being forms of vitamin B3 that play crucial roles in cellular function and energy metabolism. The distinction between the two terms is often a matter of context, with "niacinamide" commonly used in reference to skincare and supplements, and "nicotinamide" used in a more biochemical or medical context 1.
Key Differences and Similarities
- Both niacinamide and nicotinamide are derived from niacin and are vital for converting nutrients into energy, creating cholesterol and fats, repairing DNA, and exerting antioxidant effects in the body 1.
- The primary difference lies in their application and the effects they have when used in different forms. Niacinamide, when applied topically, is known for its skin benefits, including improving skin barrier function, reducing inflammation, and minimizing pore appearance 1.
- Unlike niacin, another form of vitamin B3, niacinamide/nicotinamide does not cause flushing, a common side effect associated with niacin intake, making it more tolerable for most individuals 1.
- The recommended intake of niacinamide is typically up to 900 mg/d for adults, with no adverse effects such as flushing observed at this dose, highlighting its safety profile 1.
Clinical Implications
- For patients seeking to utilize the benefits of vitamin B3 without the flushing side effect, niacinamide/nicotinamide is a preferable option. This is particularly relevant for individuals with sensitive skin or those who experience adverse reactions to niacin.
- In clinical practice, understanding the equivalence of niacinamide and nicotinamide is crucial for providing accurate advice on supplementation and skincare, ensuring that patients and patients are aware of the benefits and potential interactions of these compounds.
- The application of niacinamide in skincare products, typically at concentrations between 2-5%, can offer significant benefits for skin health, including improved barrier function and reduced inflammation, without the systemic side effects associated with oral niacin intake 1.
From the FDA Drug Label
It is unclear whether nicotinamide is formed as a precursor to, or following the synthesis of, NAD Nicotinamide does not have hypolipidemic activity; the activity of the other metabolites is unknown
The FDA drug label does not answer the question.
From the Research
Definition and Forms of Niacinamide and Nicotinamide
- Niacinamide and Nicotinamide are often used interchangeably, as they are different forms of Vitamin B3 2, 3, 4.
- Nicotinamide is the amide form of Vitamin B3, and it is a precursor of essential coenzymes for numerous reactions in the body, including adenosine triphosphate (ATP) production 4.
- Niacinamide is also known as Nicotinamide, and it is a hydrophilic endogenous substance with various effects on the skin, including antipruritic, antimicrobial, vasoactive, photo-protective, sebostatic, and lightening effects 2.
Differences in Terminology
- The terms Niacinamide and Nicotinamide are often used to describe the same compound, with Niacinamide being the more commonly used term in the context of dermatology and cosmetics 2, 5.
- Nicotinic acid, also known as Niacin, is another form of Vitamin B3, which is converted into Nicotinamide in the body 4.
- The different forms of Vitamin B3, including Niacin, Nicotinamide, and Niacinamide, have various uses and effects on the skin and body 3, 6.
Uses and Effects of Niacinamide and Nicotinamide
- Niacinamide and Nicotinamide have been shown to have various benefits for the skin, including reducing hyperpigmentation, improving skin elasticity, and preventing nonmelanoma skin cancer 3, 6, 5.
- Topical application of Niacinamide has been found to be well-tolerated and effective in reducing the progression of skin aging and hyperpigmentation 2, 6.
- Nicotinamide has also been found to have potential benefits in treating various skin conditions, including acne vulgaris, atopic dermatitis, and rosacea 4, 5.