Chronic Kidney Disease (CKD) or Acute Kidney Injury (AKI): Given the age and presentation of renal issues, CKD or AKI could be a primary concern due to various potential causes such as diabetes, hypertension, or infections that could lead to kidney damage.

Nephrotic Syndrome: Characterized by significant proteinuria, hypoalbuminemia, and edema, this condition is a common renal issue in adolescents and could be due to minimal change disease, focal segmental glomerulosclerosis, or other glomerulopathies.
Urinary Tract Infections (UTIs) or Pyelonephritis: These infections can cause renal issues and are more common in females due to anatomical reasons.
Glomerulonephritis: This includes a range of diseases that cause inflammation of the glomeruli, such as post-streptococcal glomerulonephritis, which can follow a streptococcal infection.

Alport Syndrome: A genetic disorder characterized by kidney disease, hearing loss, and eye abnormalities. It's crucial to diagnose early for appropriate management and genetic counseling.
Systemic Lupus Erythematosus (SLE): An autoimmune disease that can affect multiple organs, including the kidneys, causing lupus nephritis. Early diagnosis is critical due to the potential for severe renal and systemic complications.
Vasculitis (e.g., ANCA-associated vasculitis): Conditions like Granulomatosis with Polyangiitis (GPA) or Microscopic Polyangiitis (MPA) can cause renal failure and have a high morbidity if not promptly treated.

Cystinosis: A rare genetic disorder causing an accumulation of cystine within cells, leading to kidney damage and failure.
Primary Hyperoxaluria: A rare genetic disorder leading to excessive oxalate production, causing kidney stones and renal failure.
Fabry Disease: A genetic disorder due to the deficiency of alpha-Galactosidase A, leading to the accumulation of globotriaosylceramide in various cells, including renal cells, causing renal failure among other symptoms.