What diagnosis code can be used to order Immunoglobulin A (IgA) and Immunoglobulin M (IgM) testing?

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Last updated: March 26, 2025View editorial policy

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From the Research

To order IgA and IgM testing, you can use the diagnosis code D89.9 (Disorder involving the immune mechanism, unspecified) as a general code, as recommended by recent clinical guidelines 1. When considering the diagnosis codes for ordering IgA and IgM testing, it's essential to evaluate the patient's clinical presentation and the specific conditions being suspected or ruled out.

  • For more specific conditions, consider using D80.2 (Selective deficiency of immunoglobulin A [IgA]) or D80.4 (Selective deficiency of immunoglobulin M [IgM]), as these codes directly relate to the immunoglobulins being tested 2, 3.
  • If the testing is due to suspected infection or inflammatory conditions, R76.8 (Other specified abnormal immunological findings in serum) might be an appropriate choice, as it reflects the clinical context of the testing 4. The selection of the most appropriate code depends on the clinician's suspicion and the clinical information available, emphasizing the need for accurate and detailed documentation on the requisition form to justify medical necessity and ensure proper insurance coverage 5. Key points to consider include:
  • The clinical presentation of the patient, including symptoms and medical history.
  • The specific conditions being suspected or ruled out, such as immunodeficiencies or autoimmune diseases.
  • The importance of accurate coding for insurance coverage and medical necessity justification.
  • The utility of IgA and IgM testing in evaluating immune function, diagnosing immunodeficiencies, monitoring infections, and assessing autoimmune conditions, as discussed in recent studies 1, 3.

References

Research

Selective IgA deficiency.

Journal of clinical immunology, 2010

Research

Clinical Phenotypes of Hyper-IgM Syndromes.

The journal of allergy and clinical immunology. In practice, 2016

Research

Chapter 31: Common in vitro tests for allergy and immunology.

Allergy and asthma proceedings, 2012

Research

Quantitative serum immunoglobulin tests.

Australian family physician, 2013

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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