From the Research
Red sage root prevents thrombosis through its active compounds, including tanshinones and salvianolic acids, which inhibit platelet aggregation, thrombin, and promote fibrinolysis, as supported by the most recent study in 2024 1. The primary mechanism of action involves the inhibition of platelet aggregation by blocking thromboxane A2 formation and reducing calcium mobilization within platelets.
- The compounds also inhibit thrombin, a key enzyme in the clotting cascade that converts fibrinogen to fibrin.
- Additionally, red sage root increases fibrinolysis (the breakdown of blood clots) by enhancing tissue plasminogen activator activity.
- It also has vasodilatory effects that improve blood flow and reduce the likelihood of clot formation. These anticoagulant properties make red sage root useful in traditional Chinese medicine for cardiovascular conditions, though patients taking conventional blood thinners like warfarin, aspirin, or clopidogrel should exercise caution due to potential additive effects that could increase bleeding risk, as noted in a study from 2010 2. The typical dosage in traditional use ranges from 3-15 grams of dried root daily, usually prepared as a decoction.
- A review of herbal sources of antithrombotic activity published in 2022 3 also highlights the potential of natural products, including red sage root, in preventing thrombosis.
- Another study from 2017 4 documents the anti-coagulant activity of various plants, including red sage root, and emphasizes the need for caution when prescribing herbal drugs to patients on anticoagulant therapy.
- An earlier study from 2016 5 discusses the anticoagulant potential of polyphenol-rich extracts, which are found in red sage root, and their potential in creating new therapeutic agents or dietary supplements.