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Last updated: October 25, 2025View editorial policy

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Differential Diagnosis for Bicep Pain

  • Single most likely diagnosis
    • Bicipital Tendinitis: This is the most common cause of bicep pain, often resulting from overuse or repetitive strain on the bicep tendon, leading to inflammation and pain.
  • Other Likely diagnoses
    • Bicep Strain: A strain or pull in the bicep muscle can cause pain, usually due to sudden contraction or overstretching of the muscle.
    • Bursitis: Inflammation of the bursae around the shoulder or elbow can cause bicep pain, especially if the bursae are irritated or inflamed.
    • Radiculopathy: Nerve root irritation or compression in the neck (cervical spine) can refer pain to the bicep area.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Brachial Artery Aneurysm or Thrombosis: Although rare, a ruptured aneurysm or thrombosis of the brachial artery can cause severe bicep pain and is a medical emergency.
    • Compartment Syndrome: Increased pressure within the muscle compartments of the arm can cause severe pain, numbness, and potentially lead to permanent damage if not promptly treated.
  • Rare diagnoses
    • Tumor: Rarely, a tumor (benign or malignant) in the bicep muscle or surrounding tissues can cause pain.
    • Infection: Infections such as abscesses or osteomyelitis in the bicep area can cause pain, although these are uncommon presentations.
    • Neurological Disorders: Certain neurological conditions, such as amyotrophic lateral sclerosis (ALS), can cause muscle pain and weakness, including in the bicep area, but these are rare and typically present with a broader range of symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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