From the Guidelines
Cephalexin (Keflex) can cause flushing in some individuals, although this is not explicitly stated in the provided study 1, it is a recognized side effect of cephalosporin antibiotics. Flushing, which appears as redness of the skin particularly on the face and neck, is an uncommon but potential side effect of this antibiotic. This reaction occurs because cephalexin, like other cephalosporin antibiotics, can trigger histamine release in some individuals, leading to vasodilation of blood vessels near the skin surface.
The study 1 discusses the cross-reactivity between penicillins and cephalosporins, and although it does not directly address flushing as a side effect, it highlights the importance of considering individual responses to antibiotics. If you experience flushing while taking cephalexin, it's essential to monitor whether it's accompanied by other symptoms like itching, hives, difficulty breathing, or swelling, as these could indicate a more serious allergic reaction requiring immediate medical attention.
Key points to consider:
- Cephalexin is a commonly used oral cephalosporin in the United States 1.
- The study 1 provides a table of beta-lactam antibiotics that share side chains, which may be relevant for understanding potential cross-reactivity.
- Non–beta-lactam antibiotics may also be considered as alternatives, but they may result in added patient morbidity, mortality, and cost of care 1.
- A positive cephalosporin skin test suggests drug-specific IgE antibodies, and the patient should receive a skin test–negative alternative cephalosporin or alternate antibiotic, or the patient should undergo desensitization 1.
In clinical practice, if a patient experiences flushing while taking cephalexin, the healthcare provider should assess the severity of the reaction and consider alternative treatments if necessary, prioritizing the patient's morbidity, mortality, and quality of life 1.
From the Research
Cephalexin and Flushing
- There are no direct studies that mention cephalexin (Keflex) as a cause of flushing 2, 3, 4, 5.
- A study on the etiologies and management of cutaneous flushing discusses various causes of flushing, including medications, but does not specifically mention cephalexin 6.
- Cephalexin has been associated with other side effects, such as allergic reactions and Stevens-Johnson syndrome, but flushing is not mentioned as a common side effect 2, 3, 4.
- The studies available discuss the pharmacology, efficacy, and safety of cephalexin, but do not provide information on its potential to cause flushing 2, 3, 4, 5.