What is the effect of combining Diphenhydramine with zinc?

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From the Research

Effect of Combining Diphenhydramine with Other Substances

  • There is no direct evidence on the effect of combining diphenhydramine with zinc in the provided studies.
  • However, studies have investigated the combination of diphenhydramine with other substances, such as levofloxacin 1, cocaine 2, linezolid 3.
  • The combination of diphenhydramine with levofloxacin showed synergistic antibacterial activity against certain bacteria 1.
  • The combination of diphenhydramine with cocaine enhanced reinforcing properties in rhesus monkeys 2.
  • The combination of diphenhydramine with linezolid was associated with acute delirium in a case report 3.

Diphenhydramine Alone

  • Diphenhydramine has been shown to have many side effects, including sedation and risk of toxicity in overdose, including cardiac toxicity 4.
  • Diphenhydramine overdose can lead to severe consequences, such as seizures, dysrhythmias, coma, and death 5.
  • Recognition of early signs and symptoms of diphenhydramine toxicity is crucial, and reversal agents, such as sodium bicarbonate, may be useful in treatment 5.

References

4
Research

Diphenhydramine: Time to Move on?

The journal of allergy and clinical immunology. In practice, 2022

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