What is Linessa (levonorgestrel and ethinyl estradiol) birth control?

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From the Guidelines

Linessa is a combination oral contraceptive pill containing levonorgestrel and ethinyl estradiol, which is taken daily for 21 days followed by a 7-day break during which withdrawal bleeding occurs, and is over 99% effective when used perfectly, working by preventing ovulation, thickening cervical mucus to block sperm, and thinning the uterine lining to prevent implantation 1.

Key Points to Consider

  • Linessa is a type of combined hormonal contraceptive (CHC) that contains both an estrogen and a progestin, which are taken daily for 21 days, followed by a 7-day break during which withdrawal bleeding occurs 1.
  • The effectiveness of Linessa is estimated to be around 91% with typical use, and over 99% with perfect use, making it a highly effective method of contraception 1.
  • To use Linessa effectively, it's essential to take one pill at the same time each day, starting on the first day of your menstrual period or on the first Sunday after your period begins, and to follow your healthcare provider's instructions if you're switching from another contraceptive 1.
  • Common side effects of Linessa may include nausea, headaches, breast tenderness, and spotting between periods, while serious risks include blood clots, especially in smokers over 35 1.
  • Linessa does not protect against sexually transmitted infections, so condoms are recommended for STI prevention, and if you miss a pill, take it as soon as you remember, even if it means taking two pills in one day, and consider using backup contraception for 7 days 1.

Important Considerations

  • Before starting Linessa, it's essential to have a blood pressure measurement, and to discuss any medical conditions or concerns with your healthcare provider, as certain conditions may affect the safety and effectiveness of Linessa 1.
  • Linessa can be started at any time, but if it's started more than 5 days after your menstrual period, you should use a backup method of contraception, such as condoms, for the first 7 days 1.
  • If you have any questions or concerns about using Linessa, or if you experience any side effects or symptoms, it's essential to consult with your healthcare provider for guidance and support 1.

From the Research

Linessa (Levonorgestrel and Ethinyl Estradiol) Birth Control

  • Linessa is a form of combined hormonal contraception (CHC) that contains both estrogen (ethinyl estradiol) and progestin (levonorgestrel) 2.
  • It is a type of oral contraceptive pill that is used to prevent pregnancy 3.
  • The combination of estrogen and progestin in Linessa works by stopping or delaying ovulation, preventing implantation if fertilization has already taken place, and thickening cervical mucus to prevent sperm from reaching the egg 4, 2.
  • Linessa is a short-acting, reversible method of contraception, meaning that it can be stopped at any time if pregnancy is desired 2.
  • The effectiveness of Linessa in preventing pregnancy is high, with a failure rate of less than 1% when used correctly 3, 2.
  • Common adverse effects of Linessa include nausea, vomiting, and changes in menstrual bleeding patterns 4, 5.
  • Linessa is available by prescription only and should be used under the guidance of a healthcare provider 4, 2.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Hormonal Contraception: Systemic Estrogen and Progestin Preparations.

Clinical obstetrics and gynecology, 2021

Research

History of oral contraceptive drugs and their use worldwide.

Best practice & research. Clinical endocrinology & metabolism, 2013

Research

Emergency contraception.

Archives of family medicine, 2000

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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