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Differential Diagnosis for Hives on the Body

Single Most Likely Diagnosis

  • Acute Urticaria: This is the most common cause of hives, often triggered by allergic reactions to foods, medications, or infections. It presents with itchy, raised, and transient wheals.

Other Likely Diagnoses

  • Chronic Urticaria: Similar to acute urticaria but lasts more than 6 weeks. The cause is often autoimmune or idiopathic.
  • Insect Bites or Stings: Can cause localized or generalized hives, depending on the severity of the reaction.
  • Allergic Contact Dermatitis: A type IV hypersensitivity reaction to substances like latex, metals, or certain chemicals, leading to hives and skin inflammation.
  • Drug-Induced Urticaria: Certain medications, such as antibiotics or NSAIDs, can trigger hives as an allergic reaction.

Do Not Miss Diagnoses

  • Anaphylaxis: A severe, life-threatening allergic reaction that can present with hives, along with other symptoms like difficulty breathing, rapid heartbeat, and a drop in blood pressure. Immediate medical attention is required.
  • Mastocytosis: A condition characterized by the accumulation of mast cells in the skin, which can cause hives, flushing, and other systemic symptoms.
  • Autoimmune Disorders: Such as lupus or rheumatoid arthritis, which can have hives as part of their presentation.

Rare Diagnoses

  • Urticarial Vasculitis: An inflammation of the blood vessels presenting with hives that can last longer than 24 hours and may leave bruises.
  • Erythema Multiforme: A skin condition characterized by target lesions, which can sometimes resemble hives, often triggered by infections or medications.
  • Hereditary Angioedema: A genetic disorder that causes recurrent episodes of severe swelling, which can sometimes be confused with hives.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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