Abrysvo and Flu Vaccine Can Be Safely Administered Together
Abrysvo (RSV vaccine) and influenza vaccines can be safely administered together at the same visit, with no need to separate these vaccinations. 1
Evidence Supporting Concurrent Administration
A Phase 3 clinical trial (Study 5) specifically evaluated the concomitant administration of Abrysvo with seasonal inactivated influenza vaccine (FLUAD QUADRIVALENT) in adults ≥65 years of age, demonstrating safety and no significant interference between the vaccines 1
Within 7 days following concomitant administration, fatigue was reported by 30.0% of participants who received Abrysvo with influenza vaccine, compared to 19.1% who received Abrysvo alone and 27.1% who received influenza vaccine alone 1
No other notable differences were observed in local and systemic adverse reactions when Abrysvo was administered with influenza vaccine compared to when administered alone 1
No serious adverse events related to vaccination were reported in the concomitant administration group 1
General Principles for Vaccine Co-administration
The Centers for Disease Control and Prevention (CDC) recommends that inactivated vaccines, including RSV vaccines like Abrysvo and influenza vaccines, can be safely administered simultaneously at separate anatomic sites 2
When administering multiple vaccines simultaneously, they should be given at separate injection sites to minimize local reactions 2, 3
Individual vaccines should never be mixed in the same syringe unless specifically licensed for mixing by the FDA 2
Simultaneous administration is particularly important in certain situations, including when there is imminent exposure to several infectious diseases 2
Practical Administration Guidelines
Administer Abrysvo and influenza vaccine at different anatomical sites (e.g., different arms or different locations on the same arm separated by at least 1 inch) 2, 1
When administering vaccines with increased reactogenicity (such as adjuvanted influenza vaccines), consider injecting them into different limbs to minimize local reactions 2
Document each vaccine administered, including the anatomical site of administration 2
Potential Side Effects
Common side effects of Abrysvo include injection site pain (35.3%), fatigue (37.3%), headache (28.4%), and muscle pain (24.4%) 1
When administered with influenza vaccine, expect similar side effects with a potential slight increase in fatigue (30.0% for concomitant administration vs. 19.1% for Abrysvo alone) 1
Most solicited local and systemic reactions have a median duration of 1-2 days 1
Important Considerations
There is no need to delay vaccination to administer these vaccines separately when they can be given simultaneously 2, 3
Simultaneous administration increases the probability that patients will be fully immunized and reduces missed opportunities for vaccination 4, 2
For patients concerned about side effects, explain that concomitant administration does not significantly increase the severity of adverse reactions compared to receiving each vaccine separately 1, 5
By following these guidelines, healthcare providers can safely and effectively administer Abrysvo and influenza vaccines during the same visit, ensuring optimal protection against both RSV and influenza.