From the Guidelines
Perindopril (Coversyl) is an ACE inhibitor, not an ARB, but a comparable ARB would be valsartan or candesartan, with valsartan 80-160mg once daily or candesartan 16-32mg daily providing similar blood pressure lowering effects, as seen in the dose comparisons in 1. When considering an equivalent ARB to Perindopril, it's essential to look at the dosing and efficacy of different ARBs. According to the study 1, the goal doses for ARBs like valsartan and candesartan are 80-320mg daily and 2-32mg daily, respectively.
- Key points to consider when switching from an ACE inhibitor like Perindopril to an ARB include:
- Maintaining current blood pressure monitoring schedules
- Following up with a healthcare provider within 2-4 weeks to ensure the new medication's effectiveness
- Understanding that ARBs work by blocking angiotensin II receptors, which typically results in fewer side effects like cough compared to ACE inhibitors
- Recognizing that the specific ARB and dosage should be determined by a doctor based on individual health needs, considering factors like kidney function, heart conditions, and other medications, as discussed in 1. The decision to switch from Perindopril to an ARB like valsartan or candesartan should be made under the guidance of a healthcare provider, taking into account the patient's overall health profile and the potential benefits and risks associated with the change, as indicated by the guidelines in 1.
From the Research
Angiotensin II Receptor Blocker (ARB) Equivalent to Coversyl (Perindopril)
- There is no direct equivalent of Coversyl (Perindopril), an Angiotensin-Converting Enzyme (ACE) inhibitor, among Angiotensin II Receptor Blockers (ARBs) as they belong to different classes of antihypertensive drugs 2, 3.
- However, studies have compared the efficacy of ACE inhibitors like Perindopril with ARBs in treating hypertension, suggesting that ARBs such as losartan, valsartan, irbesartan, candesartan, telmisartan, and eprosartan are as effective as ACE inhibitors in reducing blood pressure 3.
- A specific study compared the effects of perindopril and losartan, an ARB, in the treatment of hypertension, finding that both drugs were effective in reducing blood pressure, but the twice-daily administration of the same dose of either drug had a more favorable effect on the diurnal/nocturnal blood pressure ratio compared to once-daily administration 4.
- The choice between an ACE inhibitor like perindopril and an ARB would depend on individual patient factors, including comorbidities, side effect profiles, and specific cardiovascular risk factors 5, 6.
Key Points About Perindopril and ARBs
- Perindopril is a well-tolerated ACE inhibitor effective in treating hypertension and reducing cardiovascular risk 2, 5, 6.
- ARBs are a class of drugs that block the action of angiotensin II at its receptor, providing an alternative to ACE inhibitors for blood pressure management 3.
- Both ACE inhibitors and ARBs have been shown to provide benefits in patients with hypertension, heart failure, and other cardiovascular conditions, though their mechanisms of action differ 3, 5.