Augmentin Dosage for UTI with Culture Showing Sensitivity
For a urinary tract infection with culture showing sensitivity to Augmentin, the recommended dosage is 875 mg/125 mg every 12 hours or 500 mg/125 mg every 8 hours for 7-14 days, with the 12-hour regimen preferred due to fewer gastrointestinal side effects.
Dosing Recommendations Based on UTI Classification
Uncomplicated UTI
- For uncomplicated UTIs, Augmentin (amoxicillin-clavulanate) can be administered as 500 mg/125 mg every 8 hours or 875 mg/125 mg every 12 hours 1
- The 12-hour regimen (875 mg/125 mg) is preferred as it has comparable efficacy with significantly less diarrhea compared to the 8-hour regimen 1
- Treatment duration should be 7 days for uncomplicated UTIs 2
Complicated UTI
- For complicated UTIs, the same dosing of 875 mg/125 mg every 12 hours or 500 mg/125 mg every 8 hours is recommended 1
- Treatment duration should be extended to 7-14 days for complicated UTIs 2
- For male patients (always considered complicated UTIs), treatment should be extended to 14 days when prostatitis cannot be excluded 2, 3
Clinical Evidence Supporting Recommendations
- Clinical trials demonstrated comparable efficacy between the 875 mg/125 mg every 12 hours and 500 mg/125 mg every 8 hours dosing regimens for UTIs 1
- The 12-hour regimen showed statistically significant lower rates of severe diarrhea (1% vs 2%) compared to the 8-hour regimen 1
- Bacteriological success rates were similar between both regimens at 2-4 days post-therapy (81% vs 80%), 5-9 days post-therapy (58% vs 52%), and 2-4 weeks post-therapy (52% vs 55%) 1
Administration Guidelines
- Augmentin should be taken at the start of a meal to enhance absorption of clavulanate potassium and minimize gastrointestinal intolerance 1
- For patients who have difficulty swallowing tablets, appropriate oral suspension formulations can be used 1
- Two 250 mg/125 mg tablets should not be substituted for one 500 mg/125 mg tablet as they contain different amounts of clavulanic acid 1
Important Considerations
- Local antimicrobial resistance patterns should be considered when selecting therapy 2
- Urine culture and susceptibility testing should be performed before initiating therapy, and treatment should be adjusted based on results 2
- For patients with severe infections or systemic symptoms, consider parenteral therapy initially 2
- Patients with risk factors for complicated UTIs (obstruction, foreign body, immunosuppression, etc.) may require longer treatment courses 2
Monitoring and Follow-up
- Monitor for clinical improvement within 48-72 hours of initiating therapy 2
- Consider follow-up urine culture in complicated cases to confirm eradication 2
- If symptoms persist or worsen, reevaluate diagnosis and consider alternative antimicrobial therapy based on culture results 2