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Last updated: October 27, 2025View editorial policy

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Differential Diagnosis for Rash on Arms

  • Single most likely diagnosis
    • Contact Dermatitis: This is a common condition that occurs when the skin comes into contact with an irritant or allergen, leading to a rash. The arms are a common site for contact dermatitis due to exposure to various substances.
  • Other Likely diagnoses
    • Eczema (Atopic Dermatitis): A chronic skin condition characterized by itchy, inflamed skin. The arms can be affected, especially in individuals with a history of atopic diseases.
    • Psoriasis: An autoimmune condition that speeds up the life cycle of skin cells, causing cells to build up rapidly on the surface of the skin. The arms, including the elbows, can be a common site for psoriatic plaques.
    • Allergic Reaction: An allergic reaction to substances like insect bites, certain metals (e.g., nickel), or latex can cause a rash on the arms.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Meningococcemia: A severe infection caused by Neisseria meningitidis, which can present with a rash. Although rare, it's critical to consider due to its high mortality rate if not promptly treated.
    • Rocky Mountain Spotted Fever (RMSF): A tick-borne disease that can cause a rash on the arms, among other symptoms. Early diagnosis and treatment are crucial to prevent serious complications.
    • Lyme Disease: Another tick-borne illness that can cause a rash, known as erythema migrans, which may appear on the arms.
  • Rare diagnoses
    • Pityriasis Rosea: A skin condition characterized by a rash that can appear on the arms, although it more commonly affects the trunk.
    • Keratosis Pilaris: A harmless condition that causes small, rough patches on the skin, often on the arms, but it's not typically considered in the differential for a rash.
    • Dermatomyositis: An inflammatory disease characterized by skin rash and muscle weakness. The rash can appear on the arms, but this condition is relatively rare.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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