What are the treatment options for Morton's neuroma?

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Last updated: March 26, 2025View editorial policy

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From the Guidelines

Treatment for Morton's neuroma should begin with conservative approaches, including wearing open-backed shoes, using heel lifts or orthoses, taking NSAIDs, and engaging in stretching exercises, as these methods have been shown to be effective in reducing symptoms and improving quality of life 1. When considering treatment options, it's essential to prioritize conservative approaches before moving to surgical interventions. Some key conservative methods include:

  • Wearing open-backed shoes to reduce pressure on the affected area
  • Using heel lifts or orthoses to redistribute weight away from the neuroma
  • Taking NSAIDs to reduce pain and inflammation
  • Engaging in stretching exercises to improve foot mobility and reduce pressure on the nerve It's also important to note that local injections of corticosteroids are not recommended as an initial treatment option 1. In cases where conservative treatments fail, surgical options may be considered, but the most recent and highest quality study should be consulted to determine the best course of action. The use of imaging techniques such as MRI and US can be helpful in diagnosing Morton's neuroma, with MRI showing high sensitivity and specificity in evaluating patients with metatarsalgia and Morton's neuroma 1. However, when it comes to treatment, the focus should be on conservative approaches that prioritize reducing symptoms and improving quality of life, rather than relying solely on imaging techniques or surgical interventions. Ultimately, the goal of treatment should be to alleviate pain, reduce inflammation, and improve mobility, with a focus on conservative approaches as the first line of treatment 1.

From the Research

Treatment Options for Morton's Neuroma

The treatment options for Morton's neuroma include:

  • Conservative measures such as orthotics and anti-inflammatory medication 2
  • Corticosteroid injections, which have been shown to be effective in alleviating symptoms in 90% of patients 3
  • Ultrasound-guided procedures, including infiltration of the area with a corticosteroid and local anesthetic, chemical neurolysis with alcohol or radiofrequency thermal neurolysis 2
  • Shoe modifications, which can provide complete or partial relief of pain in 63% of patients 4
  • Infiltrative treatment with substances such as steroids, sclerosing solutions, capsaicin, and hyaluronic acid, which have been shown to be effective in reducing pain related to Morton's neuroma 5
  • Ethanol injections, which have been shown to have a success rate of more than 82% per single injection 6

Efficacy of Treatment Options

The efficacy of these treatment options varies, with:

  • Corticosteroid injections showing a high level of efficacy in reducing pain 3, 5
  • Capsaicin producing a VAS score reduction of 51.8% 5
  • Alcohol and hyaluronic acid injections being well tolerated, but requiring further research to determine their effectiveness 5
  • Ethanol injections showing a high success rate of more than 82% per single injection 6

Considerations for Treatment

When considering treatment options for Morton's neuroma, it is important to note that:

  • Surgical options are typically considered only if symptoms do not improve with conservative treatment 3
  • Minimally invasive treatments can significantly reduce the need for subsequent surgery in patients with persistent Morton's neuroma unresponsive to conservative measures 2
  • The choice of treatment should be based on the individual patient's needs and medical history, and should be guided by a healthcare professional.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Ultrasound-guided treatment of Morton's neuroma.

Journal of ultrasonography, 2021

Research

Infiltrative Treatment of Morton's Neuroma: A Systematic Review.

Pain management nursing : official journal of the American Society of Pain Management Nurses, 2024

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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