What personal protective equipment (PPE) is required for a nurse to administer intravenous (IV) chemotherapy?

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Last updated: October 27, 2025View editorial policy

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Required Personal Protective Equipment for IV Chemotherapy Administration

A nurse administering intravenous chemotherapy should wear chemotherapy gloves, impervious gown, and eye protection to ensure proper protection against hazardous drug exposure.

Personal Protective Equipment Requirements

Required PPE:

  • Chemotherapy gloves - Specialized gloves designed to protect against hazardous drugs are essential when administering IV chemotherapy 1, 2
  • Impervious gown - A fluid-resistant gown that covers personal clothing and skin is required to prevent contamination from splashes or spills 1, 3
  • Eye protection - Protective eyewear or face shield should be worn to protect mucous membranes of the eyes from potential splashes 4

Not Required for Standard IV Chemotherapy Administration:

  • N95 respirator - Standard surgical masks are sufficient unless aerosolization is expected 4
  • Shoe covers - Not routinely required for IV chemotherapy administration 2, 3

Evidence-Based Rationale

Glove Requirements

  • Chemotherapy-specific gloves should be worn whenever there is potential for contact with hazardous drugs 4
  • Single gloves are the minimum requirement, though double-gloving is recommended for higher protection 1, 2
  • Studies show that while glove use has improved (95-100% compliance), proper gown use remains suboptimal (50-65%) 2

Gown Requirements

  • Gowns must be impervious/fluid-resistant to prevent seepage of hazardous drugs through the material 4
  • The gown should cover the torso and arms completely to protect skin and clothing 4
  • Only 50% of nurses reported using gowns during drug administration despite safety recommendations 2

Eye Protection

  • Eye protection is essential as chemotherapy agents can cause serious damage to mucous membranes 4
  • Face shields or protective eyewear with solid side shields are recommended to protect against splashes 4

Common Pitfalls in PPE Use

  • Inadequate gown use: Many nurses (38-42%) report never using gowns when administering chemotherapy, significantly increasing exposure risk 1
  • Improper glove selection: Regular examination gloves do not provide adequate protection against chemotherapy drugs 2
  • Reusing disposable PPE: All PPE should be considered single-use items and disposed of properly after each patient or procedure 4
  • Removing PPE in incorrect order: Proper sequence for removal prevents contamination (gloves first, followed by eye protection, then gown) 4

Implementation Considerations

  • All PPE should be readily available in appropriate sizes in areas where chemotherapy is administered 4
  • PPE should be put on immediately before handling chemotherapy and removed immediately after completion 4
  • Hands should be washed before donning and after removing gloves 4
  • All used PPE should be disposed of as hazardous waste according to institutional policies 3

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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