From the FDA Drug Label
Dosage: Usual adult dose is 4 capsules once daily or as prescribed by a licensed medical practitioner. The recommended dose of Vitamin K2 (Menatetrenone) for maintaining bone health is 4 capsules once daily as per the usual adult dose, however the exact dosage may vary based on the prescription of a licensed medical practitioner 1.
From the Research
The recommended dose of Vitamin K2 (Menatetrenone) for maintaining bone health is 100-200 micrograms daily, preferably in the MK-7 form, as supported by the most recent and highest quality study 2. This dose can be taken as a supplement, and it is essential to take it with a meal containing some fat, as it is a fat-soluble vitamin. Vitamin K2 works by activating osteocalcin, a protein that helps bind calcium to the bone matrix, thereby improving bone density and reducing fracture risk. It also helps prevent calcium from depositing in arteries and soft tissues by activating matrix Gla protein. Some key points to consider:
- Vitamin K2 works synergistically with vitamin D3 and calcium, so consider taking these together for maximum bone health benefits 3, 4.
- Most people can safely take vitamin K2 supplements, but those on blood-thinning medications like warfarin should consult with their healthcare provider before starting supplementation.
- The Institute of Medicine has increased the dietary reference intakes of vitamin K to 90 microg/d for females and 120 microg/d for males, which is an increase of approximately 50% from previous recommendations 3.
- A study published in 2015 found that daily menaquinone-7 intake ≥100 μg was suggested to improve osteocalcin γ-carboxylation 2.
- Another study published in 2013 found that 3-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women 5.