What is the typical dosage and treatment regimen for Daflon (Diosmin) 500 mg?

Daflon 500 mg Dosage and Treatment Regimen

The typical dosage for Daflon 500 mg (Diosmin) is 2 tablets daily (1000 mg total) for chronic venous insufficiency and related conditions. 1, 2

Standard Dosing Regimen

• The recommended standard dose is 2 tablets of Daflon 500 mg per day (1000 mg total daily dose), typically taken as a single daily dose 1
• For chronic venous insufficiency, this dosage has shown excellent tolerability and high patient acceptance 1, 3
• Long-term treatment at this dosage (2 tablets daily) has demonstrated sustained efficacy and safety even after one year of continuous administration 3

Specific Clinical Applications

For Chronic Venous Insufficiency (CVI):

• Standard dose: 2 tablets (1000 mg) once daily 2, 4
• Duration: Long-term therapy is well-tolerated and may be continued for extended periods (studies show safety for at least 12 months of continuous use) 3
• Clinical benefits typically begin to appear within the first two months of treatment, with approximately 50% of the total symptom improvement occurring within this timeframe 3

For Hemorrhoids:

• Standard dose: 2 tablets (1000 mg) once daily 1
• Duration: Based on symptom resolution and clinical response

Mechanism and Benefits

• Daflon 500 mg consists of a micronized fraction of flavonoids (90% diosmin and 10% hesperidin) 4
• The micronization process allows for better gastrointestinal absorption and more consistent clinical effects 1
• Key benefits include:
  • Improvement in venous tone 2, 4
  • Enhanced lymphatic drainage 2
  • Protection of the microcirculation 2, 5
  • Reduction in leg edema and circumference 2, 3
  • Relief of venous symptoms such as heaviness, pain, and paresthesia 4

Special Considerations

• Daflon 500 mg shows excellent tolerability with minimal side effects 1, 3
• The most commonly reported side effect is gastralgia (stomach pain), which occurs infrequently 3
• No significant changes in laboratory parameters have been observed during long-term administration 3
• Can be used as first-line treatment for symptoms and edema at any stage of chronic venous disease 4
• May be used in conjunction with other treatments such as compression therapy, sclerotherapy, or surgery for advanced disease stages 4

Clinical Efficacy Indicators

• Significant reduction in leg circumference measurements 2, 3
• Improvement in functional discomfort scores by approximately 80% after long-term treatment 3
• Reduction in red blood cell aggregation and improved microcirculatory blood flow 5
• Overall efficacy rated as excellent in 58% and useful in 33% of patients in long-term studies 3