From the Research
Ingrezza (valbenazine) can cause several side effects, including drowsiness, fatigue, balance problems, and restlessness, with common adverse events (≥ 4%) such as headache, somnolence, nausea, anxiety, fatigue, dry mouth, and diarrhea, as reported in the most recent study 1. The most common side effects of Ingrezza (valbenazine) include:
- Drowsiness
- Fatigue
- Balance problems
- Restlessness Some patients may experience serious side effects such as:
- Tardive dyskinesia
- Parkinsonism symptoms
- QT prolongation (a heart rhythm problem)
- Allergic reactions Approximately 5-10% of patients report experiencing somnolence or fatigue, as noted in previous studies 2, 3, 4, 5. Ingrezza works by selectively inhibiting VMAT2 (vesicular monoamine transporter 2), which regulates dopamine release in the brain, explaining why it can affect movement and energy levels 5. Patients should monitor for worsening of depression, suicidal thoughts, or unusual changes in behavior while taking this medication, and it's essential to take Ingrezza exactly as prescribed, typically once daily with or without food, and to inform your healthcare provider about all other medications you're taking to avoid potential drug interactions 1. If you experience severe side effects, contact your healthcare provider immediately rather than discontinuing the medication abruptly. The safety profile of deutetrabenazine, as reported in the most recent study 1, shows that it is generally well tolerated, with a favorable safety profile across indications.