From the Guidelines
Lamictal (lamotrigine) for bipolar disorder typically starts at a low dose of 25 mg daily for the first two weeks, then increases to 50 mg daily for weeks 3-4, with a therapeutic maintenance dose usually between 100-400 mg daily. The dosage of Lamictal (lamotrigine) for bipolar disorder is crucial for its effectiveness and safety. According to the provided evidence, there is limited information on the specific dosage of lamotrigine for bipolar disorder in the study by 1. However, based on general medical knowledge and the example provided, the dosage of lamotrigine for bipolar disorder typically starts at a low dose and gradually increases until reaching a therapeutic maintenance dose. Some key points to consider when prescribing lamotrigine for bipolar disorder include:
- Starting with a low dose to reduce the risk of serious skin rashes
- Gradually increasing the dose every 1-2 weeks
- Reaching a therapeutic maintenance dose, usually between 100-400 mg daily
- Monitoring for common side effects such as headache, dizziness, blurred vision, and nausea
- Regular follow-ups with a psychiatrist to assess effectiveness and side effects. It is essential to note that the provided evidence does not specifically address the dosage of lamotrigine for bipolar disorder, but rather discusses the treatment of bipolar disorder in children and adolescents, including the use of various medications, such as lithium, valproate, and antipsychotic agents. However, based on the example provided and general medical knowledge, the recommended dosage of lamotrigine for bipolar disorder can be determined.
From the FDA Drug Label
PACKAGE LABEL.PRINCIPAL DISPLAY PANEL NDC 70771-1514-3 Lamotrigine extended-release tablets, 25 mg Rx only 30 tablets NDC 70771-1515-3 Lamotrigine extended-release tablets, 50 mg Rx only 30 tablets NDC 70771-1516-3 Lamotrigine extended-release tablets, 100 mg Rx only 30 tablets NDC 70771-1517-3 Lamotrigine extended-release tablets, 200 mg Rx only 30 tablets NDC 70771-1518-3 Lamotrigine extended-release tablets, 250 mg Rx only 30 tablets NDC 70771-1519-3 Lamotrigine extended-release tablets, 300 mg Rx only 30 tablets The FDA drug label does not answer the question.
From the Research
Dosage of Lamictal (Lamotrigine) for Bipolar Disorder
- The dosage of lamotrigine is titrated over a 6-week period to 200 mg/day to minimize the incidence of serious rash 2, 3.
- The standard final dose is 200 mg/day, achieved with slow titration 4.
- Adjustments to the initial and target dosages are required if coadministered with valproate semisodium or carbamazepine 2, 3, 4.
- The concomitant use of lamotrigine and valproic acid requires a reduction of the standard final dosage of lamotrigine to 100 mg/day 4.
- An increase in the dosage of lamotrigine (up to a maximum of 400 mg/day) is required in the case of concomitant use of enzyme inducers, such as carbamazepine 4.
- In some studies, the mean dose of lamotrigine was 187+/-157 mg/day (range 50-600 mg/day) 5.
- In a clinical trial, lamotrigine was administered at a dose of 25 mg once daily for 1 week, 50 mg once daily for the second week, and 100 mg once daily for the last 2 weeks 6.