What is the cause of a 57-year-old female's sharp, constant right lower abdominal pain, radiating to her lower back, with a history of brain tumor, left nephrectomy (surgical removal of a kidney) due to kidney tumor, and a scheduled right partial nephrectomy (surgical removal of a portion of the kidney) for kidney cancer?

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Differential Diagnosis

  • Single most likely diagnosis
    • Renal tumor with possible local spread or metastasis: This diagnosis is most likely given the patient's known history of a right renal lesion, recent diagnosis of kidney cancer, and scheduled partial nephrectomy. The sharp, constant pain radiating to her back and the presence of a lump in her lower right abdomen are consistent with a growing tumor.
  • Other Likely diagnoses
    • Musculoskeletal pain: Given the patient's description of sharp, constant pain that worsens with activity, musculoskeletal pain is a possible diagnosis. However, the presence of a lump and radiation to her back makes this less likely.
    • Nephrolithiasis: Kidney stones could cause severe pain radiating to the back, but the patient's history and recent imaging studies make this less likely.
    • Pyelonephritis or other urinary tract infections: Although the patient has a history of kidney issues, there is no mention of fever, dysuria, or other symptoms typical of a urinary tract infection.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Metastatic disease: Given the patient's history of kidney cancer, the possibility of metastatic disease should be considered, especially with the new complaint of a lump in her lower right abdomen.
    • Retroperitoneal hemorrhage: Although less likely, a retroperitoneal hemorrhage could cause severe pain and a palpable mass, and would be a medical emergency.
    • Abdominal aortic aneurysm: This is a less likely diagnosis, but would be life-threatening if missed. The patient's age and history of kidney disease make this a possibility.
  • Rare diagnoses
    • Pheochromocytoma: A rare tumor of the adrenal gland that could cause abdominal pain and a palpable mass.
    • Retroperitoneal fibrosis: A rare condition that could cause abdominal pain and a palpable mass, although it is less likely given the patient's history and recent imaging studies.
    • Abdominal lymphoma: Although the patient had recent lymph node swelling, this was determined to be normal. However, abdominal lymphoma is a rare possibility that should be considered.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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