Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: October 28, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Palpitations

Single Most Likely Diagnosis

  • Anxiety or Stress-Related Palpitations: This is often the most common cause of palpitations, especially in individuals with a history of anxiety or stress. The physical symptoms of anxiety, such as increased heart rate and forceful heartbeat, can lead to the sensation of palpitations.

Other Likely Diagnoses

  • Atrial Fibrillation: A common cardiac arrhythmia characterized by rapid and irregular heart rhythms. It can cause palpitations, shortness of breath, and fatigue.
  • Premature Atrial Contractions (PACs) or Premature Ventricular Contractions (PVCs): These are extra heartbeats that can feel like palpitations. They are usually benign but can be bothersome.
  • Mitral Valve Prolapse: A condition where the two valve flaps of the mitral valve do not close smoothly or evenly, which can lead to palpitations among other symptoms.
  • Hypothyroidism or Hyperthyroidism: Thyroid disorders can affect heart rate, leading to palpitations. Hypothyroidism can cause bradycardia (slow heart rate), while hyperthyroidism can cause tachycardia (fast heart rate).

Do Not Miss Diagnoses

  • Myocardial Infarction (Heart Attack): Although less common, palpitations can be a symptom of a heart attack, especially in individuals with risk factors such as high blood pressure, diabetes, or a family history of heart disease.
  • Cardiac Tamponade: A serious medical condition where fluid accumulates in the sac around the heart, leading to palpitations, shortness of breath, and potentially fatal outcomes if not treated promptly.
  • Pulmonary Embolism: A blockage of an artery in the lungs that can cause palpitations, chest pain, and shortness of breath, requiring immediate medical attention.
  • Hypertrophic Cardiomyopathy: A condition where the heart muscle becomes thick, which can lead to arrhythmias and palpitations, and increases the risk of sudden cardiac death.

Rare Diagnoses

  • Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC): A rare heart condition where the muscle in the right ventricle is replaced by fat and scar tissue, leading to arrhythmias and palpitations.
  • Long QT Syndrome: A rare disorder of the heart's electrical activity that can cause sudden, uncontrollable, dangerous arrhythmias, often triggered by palpitations.
  • Pheochromocytoma: A rare tumor of the adrenal gland that can cause episodes of palpitations, hypertension, and sweating due to the excessive release of catecholamines.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.