From the Guidelines
Dukoral is an oral vaccine used to prevent cholera, consisting of killed whole-cell Vibrio cholerae O1 with purified recombinant B subunit of the cholera toxin (ctx), and is administered as two doses given 1–6 weeks apart, providing approximately 85% efficacy 6 months after immunization 1.
Key Characteristics of Dukoral
- The vaccine is most commonly administered to travelers, but its use is not universally recommended, including in the USA.
- Efficacy and duration of immunity can vary considerably between individuals, lasting up to 3 years in some cases.
- Dukoral works by stimulating the immune system to produce antibodies against the cholera toxin and bacteria, providing protection against the disease.
Administration and Protection
- The standard regimen for Dukoral involves taking two doses, 1-6 weeks apart, for adults and children over 6 years old.
- For children 2-6 years old, three doses are recommended.
- Protection begins about one week after completing the course and lasts for approximately two years for cholera.
Recommendations and Guidelines
- A live attenuated cholera vaccine, available as a single-dose oral vaccine in the United States, is recommended for adults 18–64 years of age who travel to cholera-affected areas (strong, high) 1.
- It is essential to complete the full course for optimal protection and to consult with a healthcare provider before travel to areas where cholera is endemic.
Comparison with Other Vaccines
- Other oral vaccines for cholera are available, including a variant of the WC/rBS vaccine and the CVD 103-HgR vaccine, each with its own efficacy and duration of protection 1.
From the Research
Dukoral (Cholera vaccine) Information
- There are no research papers to assist in answering this question as the provided studies are related to influenza vaccines, not the Dukoral (Cholera vaccine) 2, 3, 4, 5, 6.
- The studies provided discuss various aspects of influenza vaccines, including their composition, efficacy, and safety, but do not mention the Dukoral vaccine.
- To find information on the Dukoral vaccine, it would be necessary to consult studies or sources that specifically focus on cholera vaccines.