What is the cause of a lump (mass or lesion) on the arm?

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Last updated: February 11, 2025View editorial policy

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Differential Diagnosis for a Lump on the Arm

  • Single Most Likely Diagnosis
    • Lipoma: A benign tumor composed of fat tissue, which is the most common cause of a lump on the arm. It is usually soft, movable, and painless.
  • Other Likely Diagnoses
    • Cyst: A fluid-filled sac that can form on the arm, often due to a blocked oil gland or hair follicle. It may be tender to the touch and can become infected.
    • Abscess: A collection of pus that has built up within the tissue of the arm, often caused by a bacterial infection. It is typically painful, red, and swollen.
    • Hematoma: A collection of blood outside of blood vessels, often caused by trauma to the arm. It can be painful and may feel firm or soft to the touch.
  • Do Not Miss Diagnoses
    • Soft tissue sarcoma: A rare type of cancer that can cause a lump on the arm. Although it is unlikely, it is crucial to consider this diagnosis to ensure prompt treatment if necessary.
    • Infected sebaceous cyst: An infected cyst can lead to serious complications, such as abscess formation or sepsis, if left untreated.
    • Lymphoma: A type of cancer that can cause lymph nodes to become enlarged, forming a lump on the arm. It is essential to consider this diagnosis to ensure timely treatment.
  • Rare Diagnoses
    • Dermatofibroma: A rare, benign skin growth that can cause a lump on the arm. It is usually firm and may be itchy or tender to the touch.
    • Neurofibroma: A rare, benign tumor that arises from nerve tissue and can cause a lump on the arm. It is often associated with neurofibromatosis type 1.
    • Epidermoid cyst: A rare, benign cyst that can form on the arm, often due to a blocked hair follicle or oil gland. It may be tender to the touch and can become infected.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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