From the Research
The LabCorp test code for celiac disease testing is 164947, which is for the Celiac Disease Comprehensive Panel, as this provides a comprehensive assessment for celiac disease, including testing for tissue transglutaminase (tTG) antibodies, deamidated gliadin peptide (DGP) antibodies, and total IgA. This recommendation is based on the most recent evidence available, specifically the study published in 2024 1, which highlights the importance of laboratory testing, particularly TTG-IgA, in the diagnosis of celiac disease, with an accuracy comparable to histology. When ordering this test, patients should continue consuming gluten-containing foods prior to testing, as eliminating gluten can lead to false negative results, as noted in various studies, including those from 2000 2 and 2010 3. The test requires a blood sample and results are typically available within 2-4 days. These tests measure antibodies that the body produces in response to gluten exposure in people with celiac disease, helping clinicians make an accurate diagnosis before recommending dietary changes or further testing. Key considerations in the diagnosis and monitoring of celiac disease include the use of serological tests, such as TTG-IgA, and the potential for false negatives if patients are not consuming gluten at the time of testing, as discussed in the 2017 study 4. Given the complexities of celiac disease diagnosis and the importance of accurate testing, the Celiac Disease Comprehensive Panel offered by LabCorp is a valuable tool for clinicians, providing a thorough assessment of the patient's condition. It's also worth noting that individual tests, such as test code 164848 for tTG IgA antibodies alone, can be used as an initial screening test, but the comprehensive panel is generally recommended for its thoroughness. Overall, the choice of test should be guided by the most recent and highest quality evidence, with a focus on providing the best possible outcomes in terms of morbidity, mortality, and quality of life for patients with celiac disease.