From the FDA Drug Label
PRINCIPAL DISPLAY PANEL - Vitamin Bottle Label Safrel Melatonin 3mg Tablets: Helps establish normal sleep patterns 100%Drug-free and non-habit forming melatonin is a nighttime sleep aid for occassional sleeplessness.VeganFast Dissolve DIETARY SUPPLEMENT Melatonin 3mg Tablets 60 Count Melatonin 3mg Tablets 90 count
The dose of melatonin mentioned in the label is 3mg. The administration method is oral, as indicated by PO (per oral) and the form of tablets.
- The label does not provide information on the use of melatonin in cancer studies.
- The dose and administration method mentioned are for occasional sleeplessness and establishing normal sleep patterns 1.
From the Research
Melatonin Doses and Administration Methods in Cancer Studies
- The doses of melatonin (MLT) used in studies related to cancer vary, with a minimum dose of 3 mg and a maximum dose of 20 mg per day 2.
- Melatonin is typically administered orally, usually every night before bedtime, for a duration of 10 days to four months 2.
- One study used a preparation of melatonin with adenosine solubilized in water and stabilized with glycine, at a ratio of 1:4, for oncological treatment 3.
- The exact mechanisms behind the anticancer effects of melatonin remain unclear, but it is thought to interfere with various cancer hallmarks, including sustained proliferation, evading growth suppressors, and metastasis 4.
- Melatonin has been shown to have antioxidant, immunomodulatory, and anti-inflammatory effects, which may contribute to its anticancer activity 5, 6.
- The use of melatonin as an adjuvant therapy to reinforce the effects of chemotherapies or radiation and reduce their side effects is also being explored 6.