Urinary Tract Infection (UTI): The presence of pus cells (60) in the urine, along with an elevated CRP (16), strongly suggests an infectious process, with UTI being the most common cause of such findings.

Pyelonephritis: An infection of the kidney, which could explain the elevated CRP and the presence of pus cells in the urine. It's a more severe form of UTI that involves the upper urinary tract.
Prostatitis: Inflammation of the prostate gland, which can cause urinary symptoms and elevated inflammatory markers like CRP. The presence of pus cells in the urine supports this diagnosis, especially in male patients.
Kidney Stone with Infection: A kidney stone can obstruct the flow of urine, leading to an infection. The combination of a stone and infection could explain the elevated CRP and pus cells in the urine.

Sepsis due to Urinary Source: Although less likely, sepsis originating from a urinary source is a potentially life-threatening condition that must be considered, especially in patients with risk factors or signs of systemic infection.
Tuberculosis of the Urinary Tract: A chronic infection that can cause sterile pyuria (pus in the urine without bacterial growth on standard cultures) and elevated inflammatory markers. It's less common but critical not to miss due to its treatment implications.

Malignancy of the Urinary Tract: Certain cancers, like bladder or kidney cancer, can cause inflammation and pus in the urine, along with elevated CRP levels. While rare, these conditions are important to consider, especially in patients with risk factors or atypical presentations.
Interstitial Nephritis: An inflammation of the spaces between the renal tubules, which can be caused by drugs, infections, or other diseases. It might present with sterile pyuria and elevated inflammatory markers, making it a rare but possible diagnosis in this context.