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Last updated: October 28, 2025View editorial policy

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Differential Diagnosis for Maculopapular Rash after Eating Chicken and Rice

Single Most Likely Diagnosis

  • Food Allergy: This is the most likely diagnosis, given the temporal relationship between eating chicken and rice and the development of a maculopapular rash. A common allergen in chicken or a component of the meal could trigger an allergic reaction, manifesting as a skin rash.

Other Likely Diagnoses

  • Irritant Contact Dermatitis: If the chicken and rice were not properly handled or were contaminated, irritants could cause a contact dermatitis, leading to a maculopapular rash.
  • Gastroenteritis with Rash: Certain gastrointestinal infections can cause a rash, and if the chicken and rice were contaminated with a pathogen, this could be a possible diagnosis.
  • Drug Reaction: If the patient recently started a new medication, a drug reaction could manifest as a maculopapular rash, potentially triggered or exacerbated by the meal.

Do Not Miss Diagnoses

  • Anaphylaxis: Although anaphylaxis typically presents with more severe symptoms such as difficulty breathing, rapid heartbeat, and a drop in blood pressure, a maculopapular rash can be an early sign. It's crucial to consider anaphylaxis due to its potential for severe outcomes if not promptly treated.
  • Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN): These are severe skin conditions usually triggered by medications or infections. They can start with a maculopapular rash and progress to blistering and peeling of the skin, which can be life-threatening if not recognized and treated early.

Rare Diagnoses

  • Eosinophilic Gastroenteritis: A rare condition characterized by eosinophilic infiltration of the gastrointestinal tract, which can cause a variety of symptoms including rash, especially after eating specific foods.
  • DRESS Syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms): A rare but serious condition that can be triggered by medications or, less commonly, by infections or foods. It presents with a rash, fever, and internal organ involvement, and can be life-threatening if not recognized and treated appropriately.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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