Does Ozempic (semaglutide) expire after opening the pen?

Ozempic Expiration After Opening the Pen

Ozempic (semaglutide) pens should be discarded 56 days after opening, even if medication remains in the pen, as indicated by FDA labeling. 1

Storage and Expiration Guidelines

• Unopened Ozempic pens should be refrigerated between 36°F to 46°F (2°C to 8°C) until first use 1
• Once opened, Ozempic pens can be stored either:
  • At room temperature between 59°F to 86°F (15°C to 30°C), OR
  • In a refrigerator between 36°F to 46°F (2°C to 8°C) 1
• The opened pen must be discarded after 56 days, regardless of how much medication remains in the pen 1
• It's recommended to write the disposal date on your calendar when you first open the pen 1

Proper Handling to Maintain Efficacy

• Avoid exposing Ozempic to extreme temperatures (<36°F or >86°F) as this can lead to loss of potency 2
• Keep Ozempic away from direct heat and light 1
• Do not freeze Ozempic - frozen medication should not be used 1
• When refrigerating, do not store Ozempic pens directly next to the cooling element 1
• Avoid excessive agitation of the pen to prevent clumping, frosting, or precipitation 2

Signs of Potential Potency Loss

• Always inspect the medication before each use 2
• Semaglutide should appear clear and colorless when viewed through the pen window 1
• Do not use if the solution appears cloudy, contains particles, or has changed in appearance 1
• If uncertain about the potency of your Ozempic pen, replace it with a new one 2
• Unexplained increases in blood glucose may indicate reduced insulin potency 2

Practical Recommendations

• Always keep a spare pen available in case of loss, damage, or concerns about medication potency 1
• When traveling, continue to follow proper storage guidelines 2
• Keep the pen cap on when not in use to protect the medication from light 1
• For proper disposal, use FDA-cleared sharps disposal containers for used pens and needles 1
• Do not attempt to repair or disassemble the pen if you suspect issues with it 1

Special Considerations

• Unlike some insulin preparations that may lose potency after 30 days at room temperature, Ozempic maintains its efficacy for the full 56-day period when stored properly 2, 1
• The 56-day expiration applies regardless of the dose being used (0.25mg, 0.5mg, 1mg, or 2mg) 1
• Compounded versions of semaglutide may have different storage requirements and expiration timelines compared to FDA-approved Ozempic 3

Remember that proper storage and adherence to the 56-day expiration timeline are essential for maintaining the medication's effectiveness and safety.